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zhenglei-gao / KineticEval

An R package for kinetic evaluations
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New optimization routine #25

Open zhenglei-gao opened 10 years ago

zhenglei-gao commented 10 years ago

Maybe we can try this Nelder-Mead with box constraints.

https://github.com/lme4/lme4/blob/master/R/optimizer.R

But this does not come with a hessian, we have to calculate the hessian afterwwards.

zhenglei-gao commented 10 years ago

Must do a bechmark test some day!!!!!!!!!!