Closed no7ren closed 2 years ago
I will check it as soon as I can.
This bug only occurs when there are more than 15 different alleles at a multi-allelic site (or on a row in the VCF file).
SeqArray_1.36.2 fixes this bug. Please install SeqArray_1.36.2 from Bioconductor.
I am using the latest SeqArray package with the following command: seqGetData(f, 'genotype')
And part of the output look like: sample allele [,1] [,2] [,3] [,4] [,5] [,6] [,7] [,8] [,9] [,10] [,11] [,12] [,13] [1,] NA NA 0 NA 0 0 0 61 0 0 0 0 0 [2,] NA NA 0 NA 0 0 0 61 0 0 0 0 0 sample allele [,14] [,15] [,16] [,17] [,18] [,19] [,20] [,21] [,22] [,23] [,24] [,25] [1,] 61 0 0 0 0 0 0 20 20 0 NA NA [2,] 61 0 0 0 0 0 0 20 2 0 NA NA
while the 8th and 14th samples in the gds should contain [13, 13] instead of [61, 61]. And the 20th and 21th samples should be [4, 4] and [4, 18].
I have use the PySeqArray to confirm that the gds file looks fine where I can get the correct genotype from the same gds file. Because of the sensitivity of the data, I can only post the line of vcf file which has the problem.
chr01 10761 . CATATAT CACACACACACACACATATATATAT,CACACACACACACATATATAT,CACACACACACATATATATATATATATAT,CACATATATATAT,CACATATATATATAT,CAT,CATATATAT,CATATATATAT,CATATATATATAT,CATATATATATATAT,CATATATATATATATAT,CATATATATATATATATAT,CATATATATATATATATATAT,CATATATATATATATATATATAT,CATATATATATATATATATATATAT,CATATATATATATATATATATATATAT,CATATATATATATATATATATATATATAT,TATATAT 21797.9 . . 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