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zwdzwd / sesame

🍪 SEnsible Step-wise Analysis of DNA MEthylation BeadChips
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Sesame differential methylation mixed models / time series? #140

Open andrewjkwok opened 10 months ago

andrewjkwok commented 10 months ago

Thank you for this wonderful package.

I was looking through the vignettes on differential methylation, and was wondering if for my dataset I have multiple samples from the same individuals from different time points, does the package support mixed model testing to account for this structure in my data? I can't seem to find such functionality implemented in the DML function currently.

Many thanks in advance.

zwdzwd commented 10 months ago

Thank you for bringing this missing feature to our attention. No, current implementation doesn't support mixed effect models. But we do have plan to add it maybe in a few months. I will come back to this thread when done.

andrewjkwok commented 10 months ago

Thank you for the quick response. Would you like me to close this issue for now?