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I have been trying to build a PBPK model for asenapine in rats, since there are no readily available databases for rats as there are for humans, can someone please suggest me ways to gets the relative…
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Structures of PBPK Models across species are not consistent (unexpectedly!!). Animals differ from Human in 2 major parts of the model:
- GI Tract
- Glomerular filtration
- … and the missing (in a…
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Is there any option of changing the gastric emptying time in a simulation designed for population?
For example: I am working on a Drug Interaction model, when two models are coupled for interaction …
HTQ05 updated
7 months ago
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Dear Matt,
I would like to give an infusion of 1.5 hours into an ODE system of a minimal PBPK model. Here, the units of the compartments are obviously concentrations (nM) (not masses alone), so t…
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System: OMEdit v1.22.0-dev-161-g8eff86a43d (I think 1.22-dev jun 11) on Windows 11.
When "Enable instance API" is ON, in the following capture image, the bloodSrc component should present 5 and 4 a…
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Hi all, can everyone please have a quick look at https://fairsharing.org/Toxicology and see which toxicology related entry is missing. Please leave missing entries in the comments, or if you added som…
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Hi all,
I've been working through the large molecule PBPK model on PK-SIM published by Niederalt et al. a few months back. I appreciate the endeavour to make the fraction recycled to plasma =1 (fr…
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Hi all,
We are excited to present our PBPK model for infliximab, which is now published online in CPT: Pharmacometrics and Systems Pharmacology at https://doi.org/10.1002/psp4.12456
We show that f…
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https://github.com/metrumresearchgroup/PBPK_PC/blob/master/model/midazolamPBPK_Adult.cpp#L76
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https://pubmed.ncbi.nlm.nih.gov/32691891/
Clin Pharmacol Ther. 2020 Jul 21
Sara N Salerno, Andrea Edginton, Jacqueline G Gerhart, Matthew M Laughon, Namasivayam Ambalavanan, Gregory M Sokol, Chi D H…