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Dear OSP-community,
We have recently been working on a PBPK/PD model of nicotine and its major metabolite cotinine. The thoroughly developed parent-metabolite model is able to predict plasma concen…
LkKov updated
3 years ago
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Dear everyone,
I would like to ask you a question related to running simulation using CLI as an example bellow.
1. I downloaded a PBPK project (efavirenz from OPS-PBPK-Model-Library), in this pr…
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Hi, I am trying to re-create the PBPK model of endogenous compound (G-CDCA), I have followed all the steps given in the attached supplementary information of the article, but I am stuck at final step.…
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Dear OSP community,
I’m extending an already developed PBPK model for a compound that is metabolised by the liver to a major metabolite, in order to predict the PK in healthy volunteers.
Firstl…
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Hi, all
Recently I have read the paper "Niederalt, C., Kuepfer, L., Solodenko, J., Eissing, T., Siegmund, H. U., Block, M., ... & Lippert, J. (2018). A generic whole body physiologically based pha…
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Hi Everyone,
I really hope someone can help me here. I have built PBPK model for a small lipophilic molecule in PK-Sim. Separately, in NONMEM, I have also built a simple Emax model relating plasma co…
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Hello, we want to share our newly developed quetiapine and aripiprazole PBPK models. Would you please creat empty model repositories? @Yuri05
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Good afternoon,
Is there anyone available to critique my recent PBPK modeling work as I prepare a manuscript for submission?
Paul
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Dear OSP-Community,
We have been working on models for transporter mediated DDI predictions. Two whole-body PBPK models of probenecid (clinical OAT inhibitor) and furosemide (clinical OAT substrate…
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I want to expand the lung model.
I referenced the paper(Applied Concepts in PBPK Modeling: How to Extend an Open Systems Pharmacology Model to the Special Population of Pregnant Women(2018)) but fail…