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Hello,
Now I'm replicating the midazolam PBPK model using IV bolus data from healthy individuals, and I have couple of questions regarding the model:
Regarding the IVIVE interpretation of the valu…
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I do not see any expression of CYP enzymes in the lower panel ( shows 0 percent in front of liver periportal and liver pericentral) even upon adding the various enzymes under metabolizing enzymes in …
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How to set F and ka when known in PK-Sim?
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Hello,
I am a new PKsim's user and when I tried to save my first and successful PBPK model, I have an error message, I copied this message below.
I have 8 individual simulations and 2 population s…
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Dear community,
I’ve developed several PBPK tumor models in MoBi regarding radionuclides used in clinical practice and managed to validate these models based on scan data (n=41). The main process i…
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Hello everyone,
My team's research focuses on generic development, and we are having trouble predicting the _in vivo_ performance of one of our formulations.
I'm using PK-Sim to predict the plasma…
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Dear all,
I want to build a model of renal insufficiency. Does anyone know which literature describes the changes in kidney volume, blood flow, gastric emptying time and other related physiological …
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Greetings -
Is there an example showing an application of Sensobol to a PBPK model?
Thanks!
-A
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For the time profile plots in multiple administration simulation 3 time ranges are plotted: full range, first application range, last application range.
It should be possible to deactivate some of th…
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ASCPT 2021
P. Balazki, S. Schaller, T. Lehr
BACKGROUND: Insulin secretion rate cannot be estimated from insulin concentrations alone, as hepatic extraction varies between subjects. Plasma concent…