Open-Systems-Pharmacology OSP-based-publications-and-content issues

Open-Systems-Pharmacology / OSP-based-publications-and-content

Publications of all kind based on the Open Systems Pharmacology Suite

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Physiologically Based Pharmacokinetic Modeling to Assess Ritonavir-Digoxin Interactions and Recommendations for Co-Administration Regimens

#618 AndreDlm opened 5 days ago
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Local depletion of large molecule drugs due to target binding in tissue interstitial space

#617 Yuri05 opened 6 days ago
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Pharmacokinetics of Midazolam in preterm neonates with an insight in brain Tissue: A PBPK approach

#616 AndreDlm opened 1 week ago
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Tutorial de Modelagem Farmacocinética Baseada em Fisiologia (PBPK) em Programa de Acesso Livre

#615 Yuri05 opened 2 weeks ago
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Understanding Voriconazole Metabolism: A Middle-Out Physiologically-Based Pharmacokinetic Modelling Framework Integrating In Vitro and Clinical Insights

#614 Yuri05 opened 2 weeks ago
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Global sensitivity analysis of Open Systems Pharmacology Suite physiologically based pharmacokinetic models

#613 abdullahhamadeh opened 2 weeks ago
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Informing the risk assessment related to lactation and drug exposure: A physiologically based pharmacokinetic lactation model for pregabalin

#612 AndreDlm opened 4 weeks ago
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PBPK-based translation from preclinical species to humans for the full-size IgG therapeutic efalizumab

#611 Yuri05 opened 1 month ago
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Prediction of tissue exposures of polymyxin-B, amikacin and sulbactam using physiologically-based pharmacokinetic modeling

#610 Yuri05 opened 1 month ago
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PBPK modeling: What is the role of CYP3A4 expression in the gastrointestinal tract to accurately predict first‐pass metabolism?

#609 AndreDlm opened 1 month ago
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Development and validation of PBPK models for genistein and daidzein for use in a Next Generation Risk Assessment

#608 AndreDlm opened 1 month ago
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Physiologically-based pharmacokinetic modelling in sepsis; a tool to elucidate how pathophysiology affects meropenem pharmacokinetics: A PBPK model of meropenem in sepsis

#607 Yuri05 opened 1 month ago
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PBPK modeling of recombinant factor IX Fc fusion protein (rFIXFc) and rFIX to characterize the binding to type 4 collagen in the extravascular space

#606 Yuri05 opened 1 month ago
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Physiologically Based Pharmacokinetic Modelling in Critically Ill Children Receiving Anakinra While on Extracorporeal Life Support

#605 Yuri05 opened 1 month ago
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Physiologically-Based Pharmacokinetic Modeling of Total and Unbound Valproic Acid to Evaluate Dosing in Children With and Without Hypoalbuminemia

#604 AndreDlm opened 2 months ago
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Bioavailability of a novel sustained-release pellet formulation of 5-flucytosine in healthy-fed participants for use in patients with cryptococcal meningitis

#603 AndreDlm opened 2 months ago
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Developmental neurotoxicity evaluation of acrylamide based on in vitro to in vivo extrapolation by pregnancy PBTK modelling

#602 AndreDlm opened 2 months ago
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Physiologically Based Pharmacokinetic Modeling of Vancomycin and its Comparison with Population Pharmacokinetic Model in Neonates

#601 JanSchlender opened 2 months ago
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Physiologically based pharmacokinetic model of brivaracetam to predict the exposure and dose exploration in hepatic impairment and elderly populations

#600 AndreDlm opened 2 months ago
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Infliximab in Inflammatory Bowel Disease: Leveraging Physiologically Based Pharmacokinetic Modeling in the Clinical Context

#599 AndreDlm opened 2 months ago
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Physiologically based pharmacokinetic models for predicting lamotrigine exposure and dose optimization in pediatric patients receiving combination therapy with carbamazepine or valproic acid

#598 AndreDlm opened 2 months ago
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Analyzing parametric influences driving age-associated changes in absorption using a PBPK-GSA approach

#597 AndreDlm opened 2 months ago
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Physiologically-based pharmacokinetic/pharmacodynamic modeling of meropenem in critically ill patients

#596 JanSchlender opened 2 months ago
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Reproducibility Study on a PBPK Model of FcRn-Mediated Recycling for Large Molecules

#595 Yuri05 opened 3 months ago
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Physiologically-based pharmacokinetic modeling of pantoprazole to evaluate the role of CYP2C19 genetic variation and obesity in the pediatric population

#594 Yuri05 opened 3 months ago
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Predict the Drug–Drug Interaction of a Novel PI3Kα/δ Inhibitor, TQ-B3525, and Its Two Metabolites Using Physiologically Based Pharmacokinetic Modeling

#593 AndreDlm opened 3 months ago
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Physiologically Based Pharmacokinetic Modeling of Vancomycin in Critically Ill Neonates: Assessing the Impact of Pathophysiological Changes

#592 AndreDlm opened 3 months ago
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A Comprehensive Physiologically Based Pharmacokinetic Model for Predicting Vildagliptin Pharmacokinetics: Insights into Dosing in Renal Impairment

#591 JanSchlender opened 3 months ago
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Physiologically Based Pharmacokinetic Model for Predicting Omadacycline Pharmacokinetics and Pharmacodynamics in Healthy and Hepatic Impairment Populations

#590 JanSchlender opened 3 months ago
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3D printed benznidazole tablets based on an interpolyelectrolyte complex by melting solidification printing process (MESO-PP): An innovative strategy for personalized treatment of Chagas disease

#589 JanSchlender opened 3 months ago
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A physiologically-based pharmacokinetic modeling approach for dosing amiodarone in children on ECMO

#588 Yuri05 opened 4 months ago
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Translate Pharmacokinetics of PD-1/PD-L1 Monoclonal Antibodies from Cynomolgus Monkey to Human: Comparison of Different Approaches

#587 Yuri05 opened 4 months ago
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Labetalol Dosing in Pregnancy: PBPK/PD and CYP2C19 Polymorphisms

#586 Yuri05 opened 4 months ago
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Investigating clinical pharmacokinetics of brivaracetam by using a pharmacokinetic modeling approach

#585 AndreDlm opened 5 months ago
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Application of Physiologically Based Pharmacokinetic Modeling to Characterize the Effects of Age and Obesity on the Disposition of Levetiracetam in the Pediatric Population

#584 AndreDlm opened 5 months ago
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Physiologically-based pharmacokinetic models versus allometric scaling for prediction of tyrosine-kinase inhibitor exposure from adults to children

#583 JanSchlender opened 5 months ago
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Physiologically-based pharmacokinetic modeling to predict the exposure and provide dosage regimens of ustekinumab in pediatric patients with inflammatory bowel disease

#582 AndreDlm opened 6 months ago
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Evaluating Drug Interactions between Ritonavir and Opioid Analgesics: Implications from Physiologically Based Pharmacokinetic Simulation

#581 AndreDlm opened 6 months ago
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A physiologically-based pharmacokinetic precision dosing approach to manage dasatinib drug–drug interactions

#580 JanSchlender opened 6 months ago
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Systematic evaluation of high‑throughput PBK modelling strategies for the prediction of intravenous and oral pharmacokinetics in humans

#579 ReneGeci opened 6 months ago
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In-Depth Analysis of the Selection of PBPK Modeling Tools: Bibliometric and Social Network Analysis of the Open Systems Pharmacology Community

#578 AndreDlm opened 6 months ago
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Integrating Pharmacokinetic–Pharmacodynamic Modeling and Physiologically Based Pharmacokinetic Modeling to Optimize Human Dose Predictions for Plasmodium falciparum Malaria: a Chloroquine Case Study

#577 nicospinu opened 7 months ago
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PBPK modeling to predict the pharmacokinetics of venlafaxine and its active metabolite in different CYP2D6 genotypes and drug-drug interactions with clarithromycin and paroxetine

#576 AndreDlm opened 7 months ago
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Physiologically based pharmacokinetic modeling to predict the pharmacokinetics of codeine in different CYP2D6 phenotypes

#575 AndreDlm opened 7 months ago
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Physiologically based pharmacokinetics modeling and transporter proteomics to predict systemic and local liver and muscle disposition of statins

#574 AndreDlm opened 7 months ago
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From gains to gaps? How Selective Androgen Receptor Modulator (SARM) YK11 impact hippocampal function: In silico, in vivo, and ex vivo perspectives

#573 JanSchlender opened 7 months ago
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Dose Prediction and Pharmacokinetic Simulation of XZP-5610, a Small Molecule for NASH Therapy, Using Allometric Scaling and Physiologically Based Pharmacokinetic Models

#572 JanSchlender opened 7 months ago
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Proof of concept of physiologically based pharmacokinetic modelling in paediatric acute lymphoblastic leukaemia

#571 JanSchlender opened 7 months ago
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Exploring inter-ethnic and inter-patient variability and optimal dosing of osimertinib: a physiologically based pharmacokinetic modeling approach

#570 JanSchlender opened 7 months ago
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PBTK model-based analysis of CYP3A4 induction and the toxicokinetics of the pyrrolizidine alkaloid retrorsine in man

#569 JanSchlender opened 7 months ago
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