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I am developing a PBPK model that focuses on regional CNS distributions of drugs and as my system of ODEs increases in complexity, I run into mass balance errors. The error is about 1-2% but increases…
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One particular equation in the differentials has be a bit puzzled – the arterial ODE does not explicity account for the mass leaving the arterial space to the other organs. As shown below:
d/dt(…
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need help! my drug, logp 3.8, pka 9.2 base, is considered to be trapping in enterocyte lysosomes when po adminstration, resulting tmax delayed to 4-8 h, how can i simulate this process in pk-sim?
wdzth updated
4 years ago
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I downloaded the file
PassiveTransport_PregnantWoman.pkml
Then, when I tried to load this file in Mobi according the procedure described in:
"Applied Concepts in PBPK Modeling: How to Extend an Op…
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Just a default PBPK-model exported from PK-Sim:
```
> param
Parameter:
Path: Organism|Lumen|Stomach|DefaultCompound|Solubility table
Value: 0.00 [kg/l]
Value overrides formula: FALSE
>…
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hello，everyone
I have some difficulties, i need your kindly help.
1.how to define blood flow limited and permeation limited partitioning in pK-SIM.
2.now I have experimental data on the distributio…
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Hi, all
I am doing a vemurafenib (Log P 5.1, pka 7.1, MW 500, fu
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Hi, kylebaron. I am new to R and trying to build a PBPK model, but it failed. Could you please have a look at this? I don't know how to fix this problem. Thank you very much.
`library(mrgsolve) # …
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Dear all,
I am looking for Ketoconazole and / or Erythromycin model which I might use for a quick check. So it does not has to be the latest super sophisticated version. Pleas let me know if you have…
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Hey there,
I am currently on a project using the large molecule model setting in my simulations. However the default settings do not describe my data very well.
cmax is generally overestimated, wh…