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run_disopred.pl fails for the three titin variants A2ASS6, E9Q8K5, and E9Q8N1 (uniprot accession codes). These are very long sequences, >30000 aa. No non-standard amino acids can be found in the seque…
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I am trying to run PSMC to obtain demographic history, and am looking to call consensus sequences from my study samples.
PSMC requires a ".fq.gz" input which is typically the whole-genome diploid c…
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Hi,
I was wondering if there was going to be a new DADA2-formatted GreenGenes database based on the new release (https://forum.qiime2.org/t/introducing-greengenes2-2022-10/25291)? I was looking thr…
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docker-compose.yml:
```yml
version: '3.2'
services:
exomiser:
image: exomiser/exomiser-cli:13.2.0
user: ${UID}:${GID}
environment:
- SPRING_CONFIG_LOCATION=/exomise…
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Hi, thanks for the great tool! I notice that expecto takes a sequence around TSS to predict the tissue-specific expression values and calculate the expression difference between ref and alt sequence. …
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mavehgvs supports construction of variant strings, but it'd also be helpful to add routines to do "variant calling", eg: turn a pair of sequences into a valid MAVE-HGVS variant string.
The full HGV…
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https://github.com/ga4gh/vmc/issues/11#issue-237162358
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I have a very basic question. Why do we need an alignment to map the vcf to a reference genome? When the vcf is generated, it is already aligned against a reference, so why align it again?
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### Ask away!
I am running the wf-amplicon on PCR amplicons covering a complete virus genome (4 overlapping long amplicons per sample, pooled in one barcode) and map the reads to a reference genome o…
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> Created by **@alexanderjsummers** on 2016-01-13 17:09
> Last updated on 2018-06-09 12:08
Because of a lack of appropriate triggers (at least for composite.sil), the examples composite.sil and bsear…