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In the minimal example, the Sections are defined like so
```
"Sections": [
{
"Id": 1,
"Title": "Chapter 1",
"Content": "/Content/Section1.md"
},
{
"Id":…
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I'm not sure if this should be an issue, as it is really just a question but:
I have a whole body PBPK model consisting of 204 ODEs. The 76th ODE listed in the model block represents the compartme…
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We are pleased to announce an upcoming TWO-day OSP workshop on integrating PBPK with QSP. The workshop will take place on October 3rd and 4th, 2018.
For more Information, please check out the Works…
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Trying to run my model and during the syntax check i got the following error:
> nlmixr(pbpk)
Error in nlmixrUIModel(.model, ini, fun) :
With multiple endpoints, all residual error predictions …
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Hello,
I am trying to build a mouse PBPK model and would like to predict saliva concentrations of the drug in the mouse. Could any please advise me on how to add salivary gland/saliva component in …
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Dear colleagues
I am working on a compound which is metabolised by the liver (Phase 1) to a major metabolite, for which I have in vitro data in microsomes, hepatocytes (stability), as well as in vi…
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Dear all,
I want to introduce an endogenous protein into a PBPK model. I have observations of this protein in venous plasma.
Is there a way of implementing (i) a turnover model of a protein in th…
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Dear all,
I am currently working on a PBPK model for a substance with a target mediated drug disposition (TMDD) effect.
I would like to implement this effect in my PK-Sim model by adding a Protein …
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I have a very complex, 64 compartment model that i am trying to fit. I tried getting the model into nlmixr format and tried checking it with nlmixr(model) and received the following error:
```R
> n…
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Hey
Thank you for providing a great programme.
I am doing my thesis, working with atorvastatin, which is a substrate for the P-glycoprotein-transporter.
The data I am working with (see link belo…