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Dear all,
I am currently working on a PBPK model for a substance with a target mediated drug disposition (TMDD) effect.
I would like to implement this effect in my PK-Sim model by adding a Protein …
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I have a very complex, 64 compartment model that i am trying to fit. I tried getting the model into nlmixr format and tried checking it with nlmixr(model) and received the following error:
```R
> n…
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Hey
Thank you for providing a great programme.
I am doing my thesis, working with atorvastatin, which is a substrate for the P-glycoprotein-transporter.
The data I am working with (see link belo…
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[PBPK-Rifampin.zip](https://github.com/Open-Systems-Pharmacology/Forum/files/2365122/PBPK-Rifampin.zip)
Hi, I am working on building a Rifampin IV model. I am still working on fitting the adult mod…
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Dear all,
I would like to share some issues I have with my project and maybe anyone could have some suggestions about how can I improve my PBPK model.
I am trying to extrapolate to pediatric p…
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**SGS Exprimo** and **FU Berlin** will run a two-days hands-on PK-Sim® & MoBi® workshop on introducing PBPK for human dose projection and drug-drug interaction (DDI) prediction on 21st-22nd Feb 2019 a…
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Dear all
I am rather new to PKsim and PBPK in general. I am interested in modelling a control release formulation, for rat data.
As per my search I found the following information in the manual. I…
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Hi all,
I want to add Reference Concentration of SLCO1B1 (OATP1B1) transporter protein level in the human I want to use for some simulations. I found the following paper (open access, so attaching)…
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Hi,
I have PK sim model, in which I had to scale partition coefficients (Interstitial : plasma & Intracellular : plasma) during model development. Now, If I want an individual PK simulation, then I…
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I recently built a large PBPK model for nlmixr, so needless to say I expected issues. I got the dreaded "Error parsing model" and after a day of trace with editing in nlmixrUIModel, I found the issue …