-
Hello,
I have a few questions-
1.) As I understand it currently, the VPC, Pred vs. DV, Res vs. Time and residual distribution plots is available in PK-SIM only after certain parameters are ident…
-
Dear all, I wonder If you had came across of examples of PBPK modells for aminoglykoside antibiotics using PK-sim and /or MoBi? Are ther more than these?
https://www.ncbi.nlm.nih.gov/pubmed/26323410 …
-
Hello!
My code is too long to reproduce here, but it looks kind of like this
```R
d(M.blood)/dt = - M.blood * ( kOutM + C.blood * kA) + MC.blood * kD;
d(C.blood)/dt = - C.blood * ( kOutC + M.b…
-
Hi All,
Is anyone is aware of the validation suite in the latest version (I am missing it or don't know where to find it)? I am using version 7.3.
I have used the same in version 7.1 (when it was l…
-
I found the most challenging and tricky part of building a PBPK model is to find the reliable protein expression data. Most of the expression data from databases are RNAseq or microarray data. In rear…
-
Dear PK-Simmers,
For an oral small molecule compound with very high solubility at pH < 2-3 and very poor solubility at pH >3, I’m building a PBPK model. Naturally, the ideal workflow would have bee…
-
Dear All,
After linked PBPK model to human gene data base, I am not able to open it, the problem is
"Not a valid password."
Thanks for your help,
BR
Anis
-
Dear all,
I wanted to know how to plug enterohepatic cycle in the PBPK model (Species: Mouse). I have a second peak after oral administration and the bioavailability of my compound is superior to …
-
Hi guys,
Where can I find mice genome database, i recently saw a paper of sorafenib pbpk modeling in mice using pksim. so they might have used mice genome database right
-
I´m new in OSP and I try to apply this software to real cases. I think that to have a verified models for the usual drugs we use in clinical behaviours will be of interest for many people. I´m thinkin…