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Dear all, I wonder If you had came across of examples of PBPK modells for aminoglykoside antibiotics using PK-sim and /or MoBi? Are ther more than these?
https://www.ncbi.nlm.nih.gov/pubmed/26323410 …
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I found the most challenging and tricky part of building a PBPK model is to find the reliable protein expression data. Most of the expression data from databases are RNAseq or microarray data. In rear…
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Dear All,
After linked PBPK model to human gene data base, I am not able to open it, the problem is
"Not a valid password."
Thanks for your help,
BR
Anis
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Dear all,
I wanted to know how to plug enterohepatic cycle in the PBPK model (Species: Mouse). I have a second peak after oral administration and the bioavailability of my compound is superior to …
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Dear PK-Simmers,
For an oral small molecule compound with very high solubility at pH < 2-3 and very poor solubility at pH >3, I’m building a PBPK model. Naturally, the ideal workflow would have bee…
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Hi guys,
Where can I find mice genome database, i recently saw a paper of sorafenib pbpk modeling in mice using pksim. so they might have used mice genome database right
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I´m new in OSP and I try to apply this software to real cases. I think that to have a verified models for the usual drugs we use in clinical behaviours will be of interest for many people. I´m thinkin…
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I am trying to incorporate a subcutaneous compartment into a working iv-PBPK model to be used for population simulation. The idea is to use de-convolved cumulative-fraction absorbed profile as input…
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Dear sir
I want to install pksim for pbpk modelling. Kindly guide me about that.
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Hi
I am trying to incorporate a subcutaneous compartment into a working iv-PBPK model to be used for population simulation. The idea is to use de-convolved cumulative-fraction absorbed profile as inp…