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I am trying to incorporate a subcutaneous compartment into a working iv-PBPK model to be used for population simulation. The idea is to use de-convolved cumulative-fraction absorbed profile as input…
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Dear sir
I want to install pksim for pbpk modelling. Kindly guide me about that.
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Hi
I am trying to incorporate a subcutaneous compartment into a working iv-PBPK model to be used for population simulation. The idea is to use de-convolved cumulative-fraction absorbed profile as inp…
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I'm using PK -Sim version 7.2 and I'm having some troubles. I'm working with warfarin modeling and when I set up the characteristics of the compound I include ''total hepatic clearance'' parameter wit…
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I have been attempting to write the ODE's and model inputs using mrgsolve while using nlmixr for parameter estimation, similar to this link: https://github.com/metrumresearchgroup/mrgsolve/issues/307
…
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Hi Kyle and all,
We are using R to do PBPK modeling for food animals with MC simulation. By changing from original code using deSolve to mrgsolve, the 1000-iteration simulation time decreased from …
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Hi,
I am using PK-Sim built-in template for Rifampin. I get this error message for oral dose. Any thought?
I have ABCB1 (Efflux) OATP1B1 (Influx) as transporters
Thank you,
Farzan
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Hi,
I'm working on a compound that is diprotic base and when I use both the pka's (6.51 & 2.94) as a base the concentrations (Cmax) is very low almost 5 times lower than observed concentrations fro…
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Hello,
I'm trying to replicate a prior PBPK model of Digoxin.
The publication mentions ATP1A2 Koff and Kd values and P-gp Km and Kcat.
In the compounds- distribution- specific binding- protein…
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Hello,
I have used other software to develop the PBPK model. I am new to PKsim, but I am sure it is a powerful tool for developing PBPK model. First of all, thanks to the scientists who developed t…