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recently an interesting article from Benet et al (https://www.ncbi.nlm.nih.gov/pubmed/?term=PMID%3A+28762489 and also see the answer from Malcom Rowland and Pang: https://www.ncbi.nlm.nih.gov/pubmed/?…
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Hi,
I have been developing a model in mice using PKSim, where the model shows the drug accumulates in the brain, while my data does not. Below I've included a plot showing the arterial blood concen…
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Hi
Thank you for your work!
I am trying to simulate large models with mrgsolve. Some models are simulated OK, the another ones result in errors and stop simulation at initial step.
For example I …
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Hi,
I am building a PBPK for an orally administered drug (no IV data available as yet). I have renal Clearance value from published literature. I noticed that PK Sim calculates specific clearance fro…
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Are there plans for a 2018 PKSIM workshop?
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Hello,
I am dealing with one formulation where I am not able to captureAbsorption & elimination phase.
Can I get some hint which parameters should be modified?
Here I am attaching picture of si…
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Sorry in advance if this is a very basic question. I'm trying to discern the underlying model equations of transit between the lumen and the mucosa, and the absorption from the mucosa to the portal ve…
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Hello,
I am wondering if there is a way to assign a different plasma protein binding parameter for the same molecule in a selected tissue (i.e. liver or gut) in PK-Sim?
thanks,
Krina
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Hi,
I was wondering enterohepatic recirculation could be added in PK-Sim. I have already added Bile clearance but it doesn't seem to cause the recirculation as it happens in vivo. Hence, AUC is sever…
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Dear all,
at the moment we are internally discussing the software installation/performance validation of the OSP suite. Does someone have experience in what exactly and how one has to validate the …