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@jjgao commented on [Fri Dec 22 2017](https://github.com/cBioPortal/GSoC/issues/40)
**Background**:
Signatures of mutational processes in human cancers can be inferred from somatic mutations data…
jjgao updated
3 years ago
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Hello there!
Thank you for this awesome R package. I have a question regarding exporting files. I have run xCell on bulk RNA seq data. The usual result gives me a matrix of enriched cell types acr…
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Hi!
We are interested in training a new model for a different gene panel; the [guide](https://github.com/parklab/SigMA/wiki/Optimize) helped a lot.
We want to detect other signatures beyond Sig3…
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I am trying to plot some genes using data level 4 for my compound (BRD-K55591206) on HepG2 cells.
There are two signatures with HepG2 cells at level 5:
LJP008_HEPG2_24H:J01
POL001_HEPG2_24H:J09
…
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Hi,
thanks for developing SingleR. Great tool!
When i created object with CreateSinglerSeuratObject,
> singler = CreateSinglerObject(dir/10X/mm10, annot = NULL, "test", min.genes = 0,technology =…
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Hello,
Thank you for this tool. I am excited to try this on my multiomics data. I have run all steps smoothly until build_grn. Even build_grn step didnt produce any errors and completed successful…
momur updated
9 months ago
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Hi,
Thank you for this great package. I am running CreateBigSingleRObject for a dataset with ~22000 cells
`singler
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I'm troubleshooting a case where a user selected "geneset permutation" with a single geneset, resulting in an inflated NES and significant p-value. The stats might indicate something else to investiga…
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We have multiple gene signatures for both cell types (e.g. CD3+ = T cell) or for pathway activation (e.g. KI67+ = proliferating). Some of these are canonical, others we find from papers or from doing …
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When trying to download the `Full Signature` for [LINCS_L1000_CRISPRKO_AURKA_mean_sig](https://maayanlab.cloud/sigcom-lincs/#/MetadataSearch/Signatures?query={%22skip%22:0,%22limit%22:10,%22search%22:…