We can in the very short term get _5-10_ compounds tested for hERG.
_We need a list in the next 24 hours_ @alintheopen @tscmacdonald @JoannaUbels
Background discussion at last meeting is here:
http…
Some triazolopyrazines were found to be metabolically unstable in rats. The team need to determine if this translates to human or mouse microsomes or whether it is solely a problem in rat assays. Some…
The team need to decide which compounds to synthesise next and it would be good to have 10-20 to focus on.
ESAC made some recommendations:
- Aim for log P between 1.5 and 3.5
- Use more heteroaryls, …
Paul Willis suggested that ortho substitution on the aryl ring could aid solubility by encouraging the ring to twist out of plane and therefore prevent 'stacking' interactions. Suitable boronic acids/…
We provide an upgrade to eclib to patch-level 9, i.e. eclib-20080310.p9.spkg. This does two things:
1. Fixes a bug (found by Edray Goins and Jamie Wiegandt) in which second descent quartics were n…