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Hi all,
Is it possible to have a susie_rss() model with 1 causal variant assumption, that can be applied on the GWAS summary statistics without needing to input an LD reference panel?
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As a user, I want to know which files have been harmonised in the old format and which have been harmonised in the new format.
This information could be included in the harmonised files list via an e…
ljwh2 updated
10 months ago
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Hi! Thanks for this great paper. I have a couple of other traits that were not included in the paper that I want to check for evolutionary signatures.
I ran into an issue trying to get the tSDS score…
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Hi,
We have GWAS summary statistics for armfat percent, trunkfat percent, and waistc with the following columns (reformatted to fit MTAG defaults):
chr bpos a1 TEST n beta …
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I want to do a GBJ test for gene level using _GWAS summary statistics._ Each gene has a certain number of SNPs. For calculating the correlation matrix using `estimate_ss_cor()`, should I take all the…
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Hello,
First, thanks for amazing project and issue resolution.
I'm wondering if the message "Mean chi^2 of SNPs used to estimate Omega is low for some SNPsMTAG may not perform well in this situa…
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We have methods for associating individual genetic variants and phenotypes (https://github.com/pystatgen/sgkit/pull/16, https://github.com/pystatgen/sgkit/pull/66), but inferring associations with gen…
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I have GWAS for two traits, both are based on the same sample (N=2000). The h2 of one of the trait is very small (0.0325), and the h2 of another one is larger than 1 (1.1843).
I wonder if it is due t…
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This publication was curated some time ago, and split into 4 studies because associations were only reported in the paper for these 4 studies. However, summary statistics were later obtained manually …