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I'm encountering difficulties while attempting to estimate a whole-body PBPK model using nlmixr2. Previously, the model functioned properly, but now it fails to estimate the data accurately. Instead, …
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I tried to generate the qualification report for Fluconazole model based on files provided here:
https://github.com/Open-Systems-Pharmacology/Fluconazole-Model
However, instead of Workflow.m I hav…
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https://pubmed.ncbi.nlm.nih.gov/38140105/
Pharmaceutics. 2023 Dec 12;15(12):2765.
Wei Zhang, Qian Zhang, Zhihai Cao, Liang Zheng, Wei Hu
Abstract
Rational drug use in special populations is a c…
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### Discussed in https://github.com/nlmixr2/nlmixr2/discussions/227
Originally posted by **afee36912** May 6, 2024
I repeatedly keep on getting an unhandled error message for the lsoda solver…
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Hello.
I'm trying to scale up animal PBPK model to human PBPK model.
I make mouse, rat, dog PBPK model but there are not correaltion between these species.
So I choose all diffrent distribution mod…
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When i try to run the model fitting with nlme, i get the following error:
> fit = nlmixr(pbpk,d2,est="nlme")
unhandled error message: EE:[lsoda] 5000 steps taken before reaching tout
@(lsoda.c:7…
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Dear,
I found that if I changed the Partition coefficients selection, the predicited Cmax could have 2-fold range in my IV rat model. I wonder that whether it reasonable and why it happened?
…
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Hello.
I tried to predict ocular concentration using PK-SIM.
But there is not ocular compartment in PK-SIM.
Can you add ocular compartment in PK-SIM? or if I have to add ocular compartment by mysel…
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Please provide the link I should follow to download the example projects that can be used in tutorials with PKSim Version 11.2
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@pchelle @abdullahhamadeh We need to check this. The max build time on appveyor is 1hour
2 months ago we were at 11 min
![image](https://user-images.githubusercontent.com/1041237/92937208-0a286280…