SCAD

data splitting

python SCAD/data/split_norm/split_data_SCAD_5fold_norm.py

hyper-parameter selection for each drug

example usage:

python SCAD/model/SCAD_5foldsCV_on_source_arg.py -e FX -d Gefitinib -g _norm -adj N

retrain the model with selected hyper-parameters and test on target domain scRNA-seq data

the hyper-parameters for our best model (weight_all: under weight sampling and considering all genes) in scRNA-seq data that sequenced prior to drug treatment are kept in Supplementary Table S5 in our manuscript

example usage:

python SCAD/model/SCAD_train_binarized_5folds.py -e FX -d Gefitinib -g _norm -s 42 -h_dim 1024 -z_dim 256 -ep 20 -la1 0.2 -mbS 32 -mbT 32