search

DIYgod / RSSHub

🧡 Everything is RSSible
https://docs.rsshub.app
MIT License
34.05k stars 7.59k forks source link

科学期刊 - Nature 系列 - Nature挂了 #10448

Closed ImVictorCheng closed 2 years ago

ImVictorCheng commented 2 years ago

路由地址

/research/nature

完整路由地址

https://rsshub.app/nature/research/nature

相关文档

https://rsshub.app/nature/research/nature

预期是什么？

正常抓取内容

实际发生了什么？

Looks like something went wrong Route requested: /research/nature Error message: Cannot read properties of null (reading 'mainEntity') Helpful Information to provide when opening issue: Path: /research/nature Node version: v16.16.0 Git Hash: 7c171c8

部署

RSSHub 演示 (https://rsshub.app)

部署相关信息

No response

额外信息

无

这不是重复的 issue

github-actions[bot] commented 2 years ago
Searching for maintainers:

To maintainers: if you are not willing to be disturbed, list your username in scripts/workflow/test-issue/call-maintainer.js. In this way, your username will be wrapped in an inline code block when tagged so you will not be notified.

如果有任何路由无法匹配，issue 将会被自动关闭。如果 issue 和路由无关，请使用 NOROUTE 关键词，或者留下评论。我们会重新审核。 If there is any route not found, the issue will be closed automatically. Please use NOROUTE for a route-irrelevant issue or leave a comment if it is a mistake.

TonyRL commented 2 years ago

/test

/nature/research/nature
github-actions[bot] commented 2 years ago

Successfully generated as following:

http://localhost:1200/nature/research/nature - Success ```rss <![CDATA[Nature (Nature) | Latest Research]]> https://www.nature.com/nature/research-articles RSSHub i@diygod.me (DIYgod) zh-cn Fri, 12 Aug 2022 12:21:01 GMT 5 <![CDATA[An Asymmetric sp3–sp3 Cross-Electrophile Coupling Using ‘Ene’-Reductases]]>

Abstract

The catalytic asymmetric construction of Csp3–Csp3 bonds remains one of the foremost challenges in organic synthesis.1 Metal-catalyzed cross-electrophile couplings (XEC) have emerged as a powerful tool for C–C bond formation.2-5 However, coupling two distinct Csp3-electrophiles with high cross- and stereoselectivity continues as an unmet challenge. Here, we report a highly chemo- and enantioselective Csp3–Csp3 XEC between alkyl halides and nitroalkanes catalyzed by flavin-dependent ‘ene’-reductases. Photoexcitation of the enzyme-templated charge-transfer complex between an alkyl halide and flavin cofactor enables the chemoselective reduction of alkyl halide over the thermodynamically favored nitroalkane partner. The key C–C bond-forming step occurs via the reaction of an alkyl radical with an in situ generated nitronate to form a nitro radical anion that collapses to form nitrite and an alkyl radical. An enzyme-controlled hydrogen atom transfer affords high levels of enantioselectivity. This reactivity is unknown in small molecule catalysis and highlights the potential for enzymes to use new mechanisms to address long-standing synthetic challenges.

Author information

Authors and Affiliations

  1. Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York, USA

    Haigen Fu, Jingzhe Cao, Tianzhang Qiao & Todd K. Hyster

  2. Department of Chemistry, Princeton University, Princeton, New Jersey, USA

    Jingzhe Cao & Samuel Garfinkle

  3. Prozomix. Building 4, West End Ind. Estate, Haltwhistle, Northumberland, UK

    Yuyin Qi & Simon J. Charnock

Authors
  1. Haigen Fu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jingzhe Cao
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tianzhang Qiao
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yuyin Qi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Simon J. Charnock
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Samuel Garfinkle
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Todd K. Hyster
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Todd K. Hyster.

Supplementary information

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Fu, H., Cao, J., Qiao, T. et al. An Asymmetric sp3–sp3 Cross-Electrophile Coupling Using ‘Ene’-Reductases. Nature (2022). https://doi.org/10.1038/s41586-022-05167-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1038/s41586-022-05167-1

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

]]> Thu, 11 Aug 2022 00:00:00 GMT https://www.nature.com/articles/s41586-022-05167-1 https://www.nature.com/articles/s41586-022-05167-1 Biocatalysis Photocatalysis Science Humanities and Social Sciences multidisciplinary <![CDATA[Pandemic-Scale Phylogenomics Reveals The SARS-CoV-2 Recombination Landscape]]>

Abstract

Accurate and timely detection of recombinant lineages is crucial for interpreting genetic variation, reconstructing epidemic spread, identifying selection and variants of interest, and accurately performing phylogenetic analyses 1–4. During the SARS-CoV-2 pandemic, genomic data generation has exceeded the capacities of existing analysis platforms, thereby crippling real-time analysis of viral evolution 5. Here, we use a novel phylogenomic method to search a nearly comprehensive SARS-CoV-2 phylogeny for recombinant lineages. In a 1.6M sample tree from May 2021, we identify 589 recombination events, which indicate that approximately 2.7% of sequenced SARS-CoV-2 genomes have detectable recombinant ancestry. Recombination breakpoints are inferred to occur disproportionately in the 3’ portion of the genome that contains the spike protein. Our results highlight the need for timely analyses of recombination for pinpointing the emergence of recombinant lineages with the potential to increase transmissibility or virulence of the virus. We anticipate that this approach will empower comprehensive real time tracking of viral recombination during the SARS-CoV-2 pandemic and beyond.

Author information

Author notes

  1. These authors contributed equally: Yatish Turakhia and Bryan Thornlow

Authors and Affiliations

  1. Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA, USA

    Yatish Turakhia, Bryan Thornlow, Jakob McBroome, Nicolas Ayala, David Haussler & Russell Corbett-Detig

  2. Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA, USA

    Yatish Turakhia, Bryan Thornlow, Angie Hinrichs, Jakob McBroome, Nicolas Ayala, David Haussler & Russell Corbett-Detig

  3. Department of Electrical and Computer Engineering, University of California, San Diego, San Diego, CA, USA

    Yatish Turakhia & Cheng Ye

  4. Department of Biological Sciences, University of California, San Diego, San Diego, CA, USA

    Kyle Smith

  5. European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, UK

    Nicola De Maio

  6. Howard Hughes Medical Institute, University of California, Santa Cruz, Santa Cruz, CA, USA

    David Haussler

  7. Department of Ecology and Evolution, Research School of Biology, Australian National University, Canberra, ACT, Australia

    Robert Lanfear

Authors
  1. Yatish Turakhia
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bryan Thornlow
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Angie Hinrichs
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jakob McBroome
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Nicolas Ayala
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Cheng Ye
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Kyle Smith
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Nicola De Maio
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. David Haussler
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Robert Lanfear
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Russell Corbett-Detig
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Yatish Turakhia or Russell Corbett-Detig.

Supplementary information

Supplementary Information

This file contains Supplementary Text S1-S18 referenced in the main text; legends for Supplementary Tables 1–4 and Supplementary References.

Reporting Summary

Peer Review File

Supplementary Table S1

This file contains acknowledgments recognizing originating laboratories responsible for obtaining the specimens, as well as the submitting laboratories where the genome data were generated and shared via GISAID.

Supplementary Table S2

This file contains acknowledgments recognizing originating and submitting laboratories for data from the China National Center for Bioinformation.

Supplementary Table S3

This file contains acknowledgments recognizing originating and submitting laboratories for data from the COVID-19 Genomics UK (COG-UK) Consortium.

Supplementary Table S4

This file contains acknowledgments recognizing originating and submitting laboratories for data from the National Center for Biotechnology Information database.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark
  • © Githubissues.
  • Githubissues is a development platform for aggregating issues.