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Fabiola-Eto / MULTIPLY-Initiative

This repository hosts codelists of long-term conditions addressed in a multimorbidity study developed by researchers from the Queen Mary University of London, Welcome Trust Sanger Institute and the London School of Hygiene and Tropical Medicine.
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MULTIPLY-Initiative

DOI

Overview

This repository hosts codelists of long-term conditions and covariables used in the study 'Characterisation of multimorbidity clusters and trajectories using data-driven approaches in a nationally-representative population'. To find out more, please, see METHODS.md and multimorbidity_list.md.

Repository content

MULTIPLY_Readv2_medcode_CPRD_GOLD

Includes codelists of medical codes recorded in the primary care using Read v2 (and their correspondent CPRD GOLD medical codes) that were used to identify our list of 204 long-term conditions e covariables.

MULTIPLY_Snomed_MedCodeID_CPRD_Aurum

Contains codelists of medical codes recorded in the primary care using SNOMED (and their correspondent CPRD Aurum medical codes) that matched (via cros-mapping algorithm) either the ReadCode or ReadTerm from the CPRD GOLD codelists, also the codelist for SARS-CoV-2 provided by CPRD (n= 260). The codelists correspond to the 203 out of 204 conditions from the multimorbidity list. 'Painful conditions' was selected using only prescribing data (Prodcode/Gemscript codes). Please, note that these codelists were not submitted to clinical revision yet.

MULTIPLY_ICD10_HES

Contains the ICD-10 codelists adapted from Kuan/CALIBER and from the cross-mapping from Read v2 to ICD-10 codes using the UK Biobank lookup file. The adaptations include the addition of relevant codes, exclusion of inadequate codes and grouping of conditions according to extensive clinical revision. Please, note that i. 'Painful conditions' was not included in the overall file of ICD-10 codes, since this condition was selected using prescribing data (Prodcode/Gemscript codes) only.

MULTIPLY_OPCS4_HES

Contains the OPCS-4 codelists generated from clinical revision and comparison between the codelists i. adapted from the CALIBER research group work, and ii. cross-mapped from the Read v2 code lists. The UK Biobank lookup file was used to cross-map the codes. The OPCS4.9 from NHS TRUD was used as a dictionary of OPCS4 codes and description.

MULTIPLY_Prodcode_CPRD_GOLD and MULTIPLY_ProdcodeID_CPRD_Aurum

Contains the Prodcode/Gemscript codelists used to select 'Menopause', 'Constipation' and 'Painful conditions' based on prescribing data found in CPRD GOLD and Aurum. Note that for 'Constipation' and 'Painful conditions' we adopted the codelists defined by the CPRD@Cambridge group. The original codelists can be found here. Additionaly, clinical criteria were applied to identify those conditions according to frequency of prescription within an interval. To learn more, please see Issues #177 and #178.

MULTIPLY_combined_codelists

Contains all codelists combined into a single file according to type of medical code.

resolved_remission_codes

Please, see Issue Resolved codes #10 and Issue Resolution/remission/cure of conditions #194.