Covid-19 Prevention Clinical Trials Repository

Original article published by Gabriel S. Gonçalves with the title "Urgent call for Data on the prophylactic use of Hydroxychloroquine for Covid-19"

Current clinical trials investigating drugs against the Covid-190

• Post-exposure Prophylaxis/Preemptive Therapy for SARS-Coronavirus-2 (COVID-19 PEP, NCT04308668
• Treatment of COVID-19 Cases and Chemoprophylaxis of Contacts as Prevention (NCT04304053)

Results for clinical trials for Covid-19

• Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial
• Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial

In vitro inhibition of SARS-Cov-2 Chloroquine and Hydroxychloroquine

• Chloroquine is a potent inhibitor of SARS coronavirus infection and spread
• Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
• Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro
• Chloroquine analogues in drug discovery: new directions of uses, mechanisms of actions and toxic manifestations from malaria to multifarious diseases

SARS-Cov-2 evolution and outbreak

• A pneumonia outbreak associated with a new coronavirus of probable bat origin

Open Data projects

• Zika researchers release real-time data on viral infection study in monkeys