This non-uniform nomenclature is confusing and wrong to use for single Mutations.
We should rename it in something like Mutation Profiles of VOC/VOIs. Maybe we should even split the Variants of interest into Variants of Concern, Variants of Interest, Variants Under Monitoring and find an automated way to get the latest Variants of something. Maybe pangolin repo offers VOCs, VOIs, and VUMs.
Variants of Concern (VOC)
A SARS-CoV-2 variant that meets the definition of a VOI (see below) and, through a comparative assessment, has been demonstrated to be associated with one or more of the following changes at a degree of global public health significance:
Increase in transmissibility or detrimental change in COVID-19 epidemiology; OR
Increase in virulence or change in clinical disease presentation; OR
Decrease in effectiveness of public health and social measures or available diagnostics, vaccines, therapeutics.
Variants of Interest (VOI)
A SARS-CoV-2 variant :
with genetic changes that are predicted or known to affect virus characteristics such as transmissibility, disease severity, immune escape, diagnostic or therapeutic escape; AND
Identified to cause significant community transmission or multiple COVID-19 clusters, in multiple countries with increasing relative prevalence alongside increasing number of cases over time, or other apparent epidemiological impacts to suggest an emerging risk to global public health.
Variants Under Monitoring (VUM)
A SARS-CoV-2 variant with genetic changes that are suspected to affect virus characteristics with some indication that it may pose a future risk, but evidence of phenotypic or epidemiological impact is currently unclear, requiring enhanced monitoring and repeat assessment pending new evidence.
AKBrueggemann
commented
2 years ago
In the config.yaml, the "variants to be highlighted" are called
variants of concern(https://github.com/IKIM-Essen/uncovar/blob/master/config/config.yaml#L89).In the report, the "variants to be highlighted" are called"
Variants of interest(https://github.com/IKIM-Essen/uncovar/blob/master/workflow/scripts/generate-overview-table.py#L206).This non-uniform nomenclature is confusing and wrong to use for single Mutations.
We should rename it in something like
Mutation Profiles of VOC/VOIs. Maybe we should even split theVariants of interestintoVariants of Concern,Variants of Interest,Variants Under Monitoringand find an automated way to get the latest Variants of something. Maybe pangolin repo offers VOCs, VOIs, and VUMs.Who definitions are: (https://www.who.int/en/activities/tracking-SARS-CoV-2-variants/)
Variants of Concern (VOC) A SARS-CoV-2 variant that meets the definition of a VOI (see below) and, through a comparative assessment, has been demonstrated to be associated with one or more of the following changes at a degree of global public health significance:
Variants of Interest (VOI) A SARS-CoV-2 variant :
Variants Under Monitoring (VUM) A SARS-CoV-2 variant with genetic changes that are suspected to affect virus characteristics with some indication that it may pose a future risk, but evidence of phenotypic or epidemiological impact is currently unclear, requiring enhanced monitoring and repeat assessment pending new evidence.