The SPARE package enables recurrent event analysis for GWAS. SPARE applies a saddlepoint approximation to achieve statistical accuracy for low-frequency variants.
The software can be downloaded in R by:
library(devtools)
install_github('JasperHof/SPARE')
library(SPARE)The R package enables a GWAS for .bed and .bgen files using the functions 'SPARE.bed' and 'SPARE.bgen'. Information and examples for running the code can be found by running '?SPARE.bed' and '?SPARE.bgen'.
A manual for using the SPARE package is included in the repository.
Please do not hesitate to contact me (Jasper.Hof@radboudumc.nl) in case you have any questions or if you encounter a problem in your analysis :-).