Large-scale analysis available

Katsevich-Lab / sceptre

An R package for single-cell CRISPR screen data analysis emphasizing statistical rigor, massive scalability, and ease of use.

https://katsevich-lab.github.io/sceptre/

GNU General Public License v3.0

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Large-scale analysis available #15

Closed Ruleof6 closed 2 years ago

Ruleof6 commented 2 years ago

Hi,

Is the large scale analysis available? We have an extensive dataset consisting of >500k cells and an MOI above 100. Seeing similar issues as described in your paper with inflated NTC p values using Monocles negative binomial model and your tool seems much more suitable.

Best,

James

timothy-barry commented 2 years ago

Hi James,

Thanks reaching out. The large-scale analysis pipeline is not quite available, but we should be able to set you up with a beta version. It would be best to discuss this over Zoom. Does this sound like a good plan to you? If so, could you please send me an email at tbarry2@andrew.cmu.edu?

Tim

timothy-barry commented 2 years ago

Just noting here that we are communicating instead over Zoom and email. Closing issue.