error: Gateway Timeout when loading library

[mansi-aggarwal-2504]

Hello, I am continuously getting this error today

> library("multiMiR")
Error: package or namespace load failed for ‘multiMiR’:
 .onLoad failed in loadNamespace() for 'multiMiR', details:
  call: NULL
  error: Gateway Timeout

> sessionInfo()
R version 4.2.1 (2022-06-23)
Platform: aarch64-apple-darwin20 (64-bit)
Running under: macOS Monterey 12.4

Matrix products: default
LAPACK: /Library/Frameworks/R.framework/Versions/4.2-arm64/Resources/lib/libRlapack.dylib

locale:
[1] en_AU.UTF-8/en_AU.UTF-8/en_AU.UTF-8/C/en_AU.UTF-8/en_AU.UTF-8

attached base packages:
[1] stats     graphics  grDevices utils     datasets  methods   base     

loaded via a namespace (and not attached):
 [1] Rcpp_1.0.11            BiocManager_1.30.22    GenomeInfoDb_1.34.9    XVector_0.38.0        
 [5] pillar_1.9.0           compiler_4.2.1         bitops_1.0-7           zlibbioc_1.44.0       
 [9] tools_4.2.1            digest_0.6.33          bit_4.0.5              evaluate_0.22         
[13] RSQLite_2.3.1          memoise_2.0.1          lifecycle_1.0.3        tibble_3.2.1          
[17] png_0.1-8              pkgconfig_2.0.3        rlang_1.1.1            cli_3.6.1             
[21] DBI_1.1.3              rstudioapi_0.15.0      yaml_2.3.7             xfun_0.40             
[25] fastmap_1.1.1          GenomeInfoDbData_1.2.9 httr_1.4.7             dplyr_1.1.3           
[29] knitr_1.44             Biostrings_2.66.0      IRanges_2.32.0         S4Vectors_0.36.2      
[33] generics_0.1.3         vctrs_0.6.4            stats4_4.2.1           bit64_4.0.5           
[37] tidyselect_1.2.0       Biobase_2.58.0         glue_1.6.2             R6_2.5.1              
[41] fansi_1.0.5            AnnotationDbi_1.60.2   XML_3.99-0.14          rmarkdown_2.25        
[45] tidyr_1.3.0            purrr_1.0.2            blob_1.2.4             magrittr_2.0.3        
[49] scales_1.2.1           htmltools_0.5.6.1      BiocGenerics_0.44.0    KEGGREST_1.38.0       
[53] colorspace_2.1-0       utf8_1.2.4             RCurl_1.98-1.12        munsell_0.5.0         
[57] cachem_1.0.8           crayon_1.5.2 

Any suggestions on what might be the issue?

[EstherUEBVHIR]

Hello Mansi, The same is happening to me. Is this issue related with the server of MultiMir being down? Any help will be appreciated

[mansi-aggarwal-2504]

Hi Esther, I think not. When the server is down, the error is something like error: Failed to connect to multimir.org port 80: Connection refused (also see here).

I am not sure and haven't still figured out how to resolve the error that I have posted though. Let me know if you find something in the meantime, thanks.

[JianxiangGegenWang]

Hi all,

Just to confirm I bumped into similar problem in different setting.

> library(multiMiR)
Error: package or namespace load failed for ‘multiMiR’:
 .onLoad failed in loadNamespace() for 'multiMiR', details:
  call: NULL
  error: Gateway Timeout

> sessionInfo()
R version 4.3.1 (2023-06-16 ucrt)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 10 x64 (build 19045)

Matrix products: default

locale:
[1] LC_COLLATE=English_United States.utf8  LC_CTYPE=English_United States.utf8    LC_MONETARY=English_United States.utf8
[4] LC_NUMERIC=C                           LC_TIME=English_United States.utf8    

attached base packages:
[1] stats4    stats     graphics  grDevices utils     datasets  methods   base     

other attached packages:
[1] DOSE_3.26.2           org.Hs.eg.db_3.17.0   AnnotationDbi_1.62.2  IRanges_2.34.1        S4Vectors_0.38.2     
[6] Biobase_2.60.0        BiocGenerics_0.46.0   clusterProfiler_4.8.3 readxl_1.4.3         

loaded via a namespace (and not attached):
  [1] DBI_1.1.3               bitops_1.0-7            gson_0.1.0              shadowtext_0.1.2       
  [5] gridExtra_2.3           rlang_1.1.1             magrittr_2.0.3          compiler_4.3.1         
  [9] RSQLite_2.3.1           png_0.1-8               vctrs_0.6.4             reshape2_1.4.4         
 [13] stringr_1.5.0           pkgconfig_2.0.3         crayon_1.5.2            fastmap_1.1.1          
 [17] XVector_0.40.0          ggraph_2.1.0            utf8_1.2.4              HDO.db_0.99.1          
 [21] enrichplot_1.20.3       purrr_1.0.2             bit_4.0.5               zlibbioc_1.46.0        
 [25] cachem_1.0.8            aplot_0.2.2             jsonlite_1.8.7          GenomeInfoDb_1.36.4    
 [29] blob_1.2.4              BiocParallel_1.34.2     tweenr_2.0.2            parallel_4.3.1         
 [33] R6_2.5.1                stringi_1.7.12          RColorBrewer_1.1-3      cellranger_1.1.0       
 [37] GOSemSim_2.26.1         Rcpp_1.0.11             downloader_0.4          Matrix_1.5-4.1         
 [41] splines_4.3.1           igraph_1.5.1            tidyselect_1.2.0        qvalue_2.32.0          
 [45] rstudioapi_0.15.0       viridis_0.6.4           codetools_0.2-19        lattice_0.21-8         
 [49] tibble_3.2.1            plyr_1.8.9              treeio_1.24.3           withr_2.5.1            
 [53] KEGGREST_1.40.1         gridGraphics_0.5-1      scatterpie_0.2.1        polyclip_1.10-6        
 [57] Biostrings_2.68.1       ggtree_3.8.2            pillar_1.9.0            BiocManager_1.30.22    
 [61] ggfun_0.1.3             generics_0.1.3          RCurl_1.98-1.12         ggplot2_3.4.4          
 [65] tidytree_0.4.5          munsell_0.5.0           scales_1.2.1            glue_1.6.2             
 [69] lazyeval_0.2.2          tools_4.3.1             data.table_1.14.8       fgsea_1.26.0           
 [73] XML_3.99-0.14           fs_1.6.3                graphlayouts_1.0.1      fastmatch_1.1-4        
 [77] tidygraph_1.2.3         cowplot_1.1.1           grid_4.3.1              ape_5.7-1              
 [81] tidyr_1.3.0             colorspace_2.1-0        nlme_3.1-162            GenomeInfoDbData_1.2.10
 [85] patchwork_1.1.3         ggforce_0.4.1           cli_3.6.1               fansi_1.0.5            
 [89] viridisLite_0.4.2       dplyr_1.1.3             gtable_0.3.4            yulab.utils_0.1.0      
 [93] digest_0.6.33           ggrepel_0.9.4           ggplotify_0.1.2         farver_2.1.1           
 [97] memoise_2.0.1           lifecycle_1.0.3         httr_1.4.7              GO.db_3.17.0           
[101] bit64_4.0.5             MASS_7.3-60    

[smahaffey]

@mansi-aggarwal-2504 @EstherUEBVHIR @JianxiangGegenWang I'm sorry for the inconvenience. It was related to the failure of the database connection. It is fixed now. Please let me know if you are having any more trouble with it.

[mansi-aggarwal-2504]

Hi @smahaffey, yes, it's working now. Thank you for your help!