Nextomics / NextDenovo

Fast and accurate de novo assembler for long reads
GNU General Public License v3.0
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Low performance with highly repeated regions #173

Closed leone93 closed 1 year ago

leone93 commented 1 year ago

I'm using the last version of the software 2.5.2 to assembly some HiFi reads of different plant species (with coverage over 60x). I notice that if the content of transposable elements (or generally repeated regions) increased, the contiguity of the asseambly drop substancially. Do you have any idea of the parameter that maybe is possible to tweak to solve this things? Thanks

moold commented 1 year ago

As I said in other issues, NextDenovo is not optimized for hifi data, so try other assemblers first.