OpenSourceMycetoma / Series-3-Phenothiazines

Project for the development of phenothiazine (and related tricyclic) anti-fungal drugs
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Where should we start? #2

Closed MFernflower closed 1 year ago

MFernflower commented 6 years ago

A Canadian company known as Toronto Research Chemicals offers a selection of ready made phenothiazines and it appears they offer international shipping!

Below is a list of compounds I feel might be worth screening and there respective prices:

H297413 10-hexylphenothiaizne 10 mg for 40 USD (currently out of stock) P318060 phenothiazine-10-propionitrile 50 mg for 110 USD (in stock) M264955 10-(4-Methoxyphenyl)-10H-phenothiazine 100 mg for 45 USD (currently out of stock) M304525 10-[2-(2-Methoxyethoxy)ethyl]-10H-phenothiazine 1 gram for 80 USD (currently out of stock) M326370 α-Methyl-phenothiazine-10-ethanol 100 mg for 150 USD (in stock) P811230 N-Propionyl Phenothiazine 500 mg for 65 USD (in stock)

Phenothiazines approved or once approved for use in human OR livestock medicine:

C424750 Chlorpromazine HCL 10 grams for 65 USD (in stock) P755790 Prochlorperazine 25 mg for 170 USD (in stock) P475190 Pipamazine 100 mg for 75 USD (in stock)

Dr. Chris Swain @drc007 recommended that we screen imipramine as it is rather close to chlorpromazine: https://www.sigmaaldrich.com/catalog/product/sigma/i7379?lang=en&region=US

Analogues of imipramine can easily be made from cheap as chips precursors (SA sells the tricyclic ring system for 96 US cents a gram at 97% purity Aldrich I1308 ) c_swain2

Please note that all the commercial suppliers I checked do not appear to have any interesting imipramine analogues so student synthesis would be required @mattodd