Project for the development of phenothiazine (and related tricyclic) anti-fungal drugs
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Series 3: A tricyclic antifungal drug devlopment project
Advantages:
Disadvantages:
- Some tricyclic drugs may cause a tetracycline-like photosensitivity in vivo (We will need to research this more)
- Water solubility is not great
- Agranulocytosis is rare side effect reported from long term use from some but not all drugs in this class (We will need to research this more)
- Parent drugs are neurological ones (the exception being the curaxin-NEU tricyclics)
with some rather unpleasant side-effects