Sourcing phenothiazines from commercial sources?

[MFernflower]

Since all of the labs in the MYOS program are busy working on other projects - I will float the idea of buying one or two of these s3 compounds (N-substituted-phenothiazines) from a commercial source just to see if they are effective against mycetoma/are worth following up on.

https://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=166278&ExtHyperLink=1 - 25mg bottle is 211 USD (seems to be only supplier????) - N-phenethyl-phenothiazine

https://www.ambeed.com/products/15375-48-1.html 100mg bottle is 122 USD - N-propyl-phenothiazine

https://www.matrixscientific.com/059688.html Fenethazine monohydrochloride 1/2 gram bottle is 171 USD

https://www.tcichemicals.com/US/en/p/M3068 - Some organic semiconductor material called MEEPT - 10 grams of liquid product 278 dollars - Looks like it could be worthy to test

For such simple compounds that seems like a lot of money but if a member of @OpenSourceMycetoma/corecontrib has some university budget perhaps it could be done?

Callback to issue #2 where I mentioned a company called Toronto research chemicals

[MFernflower]

@bebi78 is one or two of these within reach of you allotted budget?

[MFernflower]

Fenethazine monohydrochloride and N-phenethyl-phenothiazine are the two I think would prove the most interesting

[MFernflower]

Issue #1 talked about this a long time ago (just as a cross reference)

[MFernflower]

Spreadsheet for upcomming meeting is here https://github.com/OpenSourceMycetoma/Series-3-Phenothiazines/blob/master/PHENOTHIAZINE_WISHLIST.xlsx

[bebi78]

@MFernflower Sorry, I don't have money left at the moment. So we might either ask providers for free samples of ca. 2-3 mg, or students of @JuliaSarju might prepare them.

[JuliaSarju]

We think the first 2 should be ok to make. Happy to give it ago once term starts :) Dr Julia Sarju FHEA , [image: A button with "Hear my name" text for name playback in email signature] https://www.name-coach.com/julia-sarju She/Her Lecturer in Chemistry, Year One Leader, and Chemistry Disability Contact The University of York

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On Mon, 14 Aug 2023 at 15:57, bebi78 @.***> wrote:

@MFernflower https://github.com/MFernflower Sorry, I don't have money left at the moment. So we might either ask providers for free samples of ca. 2-3 mg, or students of @JuliaSarju https://github.com/JuliaSarju might prepare them.

— Reply to this email directly, view it on GitHub https://github.com/OpenSourceMycetoma/Series-3-Phenothiazines/issues/7#issuecomment-1677492563, or unsubscribe https://github.com/notifications/unsubscribe-auth/A4LEEABBMYFG7B7E7NVPCU3XVI4EDANCNFSM6AAAAAA3B7DYPM . You are receiving this because you were mentioned.Message ID: @.*** com>

[MFernflower]

Closing as between the compounds from NEU and the ones being made at York we now have a good jump start to this project