PathwayCommons / chibe

Pathway visualization and analysis tool for Pathway Commons and other BioPAX data
Eclipse Public License 1.0
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ChiBE: Chisio BioPAX Editor

Chisio BioPAX Editor, or simply ChiBE, is a free editing and visualization tool for pathway models represented by the BioPAX format, using SBGN Process Description Language, based on Chisio.

The tool features user-friendly display, viewing, and editing of pathway models. Pathway views are rendered in a feature-rich format, and may be laid out and edited with state-of-the-art layout and visualization technologies. In addition, facilities for querying a set of integrated pathways in Pathway Commons are provided. Furthermore, visualization of experimental data, including cancer genomics data of the cBioPortal, overlaid on pathway views is supported in ChiBE. These capabilities are organized around a genomics-oriented workflow and offer a unique comprehensive pathway analysis solution for genomics researchers.

ChiBE is a Java application running on various platforms including Windows XP/Vista/7, Linux, and Mac OS X. It was built using Chisio 2.0 and Eclipse GEF 3.1 for graph visualization, Paxtools for accessing and manipulating BioPAX files, and PATIKAmad for experiment data analysis.

ChiBE 2.2 User's guide

For a quick guide on how to explore pathways in Pathway Commons, please see this wiki page.

Download

ChiBE is distributed under Eclipse Public License.

Below are latest builds of ChiBE.

Below are the latest releases of ChiBE 2.2 for different platforms.

Please contact us if you need a build for another platform.

Please see the setup guide for running ChiBE from sources, and quick start guide for fast examples.

Highlights

Following are sample screenshots showing tool highlights.

Click on the figure to see the entire screenshot.

Sample Pathways

Following are images of pathway models produced by ChiBE taken from some prominent databases.

Click on the figure to see the entire screenshot.

(left) ERK/MAPK targets from Reactome (middle) Class IB PI3K non-lipid kinase events from NCI PID (right) Hedgehog signaling pathway from The Cancer Cell Map

Release Notes for Version 2.2 (June 24, 2014)

Release Notes for Version 2.1 (June 26, 2013)

Release Notes for Version 2.0 (January 9, 2013)

Release Notes for Version 1.1 (July 10, 2009)

Team

ChiBE's requirements were determined by OB, UD, ED, NS, and CS. The software design and development were mainly performed by OB, with help from MC, AA, and UD.

Acknowledgements

We would like to thank IntelliJ for providing a free open source license for IDEA.

IntelliJ IDEA

Publications

Babur, Ö., Dogrusoz, U., Çakir, M., Aksoy, B. A., Schultz, N., Sander, C., & Demir, E. (2014). Integrating biological pathways and genomic profiles with ChiBE 2. BMC genomics, 15(1), 642.

Babur, O., Dogrusoz, U., Demir, E., & Sander, C. (2010). ChiBE: interactive visualization and manipulation of BioPAX pathway models. Bioinformatics, 26(3), 429-431.