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PaulingLiu / ROGUE

Assessing the purity of single cell population
BSD 3-Clause "New" or "Revised" License
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what's the NA mean in the rouge result #6

Closed xinmiaoyan closed 3 years ago

xinmiaoyan commented 3 years ago

thanks for building so nice tools. I got a problem about the result interpretation. I know a ROGUE value of 1, indicating it is a completely pure subtype or state. In contrast, a population with maximum summarization of significant ds will yield a purity score of ~0. but There're several NA in the result, how do we interpret the NA value?

appreciate your response.

PaulingLiu commented 3 years ago

Hi @xinmiaoyan ,

Thanks for using this tool. The ROGUE will return a "NA" if a cluster from a given sample contains <10 cells (by default). In such cases, we feel that the purity assessment may not be accurate, and would filter out such NA values.

Please let me know if this is helpful.

xinmiaoyan commented 3 years ago

Hi PaulingLiu/ROGUE, Thanks for your response, it helps a lot. Have a great day!

Best, Xinmiao Yan

On Mon, Aug 23, 2021 at 10:12 AM PaulingLiu @.***> wrote:

Hi @xinmiaoyan https://github.com/xinmiaoyan ,

Thanks for using this tool. The ROGUE will return a "NA" if a cluster from a given sample contains <10 cells (by default). In such cases, we feel that the purity assessment may not be accurate, and would filter out such NA values.

Please let me know if this is helpful.

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