######################################################### XCP-D : A Robust Postprocessing Pipeline of fMRI data #########################################################
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This fMRI post-processing and noise regression pipeline is developed by the
Satterthwaite lab at the University of Pennslyvania <https://www.satterthwaitelab.com/>
(XCP\; eXtensible Connectivity Pipeline) and
Developmental Cognition and Neuroimaging lab at the University of Minnesota <https://innovation.umn.edu/developmental-cognition-and-neuroimaging-lab/>
(-D\CAN)
for open-source software distribution.
About
XCP-D paves the final section of the reproducible and scalable route from the MRI scanner to functional connectivity data in the hands of neuroscientists. We developed XCP-D to extend the BIDS and NiPrep apparatus to the point where data is most commonly consumed and analyzed by neuroscientists studying functional connectivity. Thus, with the development of XCP-D, data can be automatically preprocessed and analyzed in BIDS format, using NiPrep-style containerized code, all the way from the scanner to functional connectivity matrices.
XCP-D picks up right where fMRIprep <https://fmriprep.org>
ends, directly consuming the outputs
of fMRIPrep.
XCP-D leverages the BIDS and NiPreps frameworks to automatically generate denoised BOLD images,
parcellated time series, functional connectivity matrices, and quality assessment reports.
XCP-D can also process outputs from: NiBabies <https://nibabies.readthedocs.io>
,
ABCD-BIDS <https://github.com/DCAN-Labs/abcd-hcp-pipeline>
,
Minimally preprocessed HCP <https://www.humanconnectome.org/study/hcp-lifespan-development/\ data-releases>
,
and UK Biobank <https://doi.org/10.1016/j.neuroimage.2017.10.034>
_ data.
Please note that XCP is only compatible with HCP-YA versions downloaded c.a. Feb 2023 at the moment.
.. image:: https://raw.githubusercontent.com/pennlinc/xcp_d/main/docs/_static/xcp_figure_1.png
See the documentation <https://xcp-d.readthedocs.io/en/latest/>
_ for more details.
Why you should use XCP-D
XCP-D produces the following commonly-used outputs: matrices, parcellated time series,
dense time series, and additional QC measures.
XCP-D is designed for resting-state or pseudo-resting-state functional connectivity analyses.
XCP-D derivatives may be useful for seed-to-voxel and ROI-to-ROI functional connectivity analyses,
as well as decomposition-based methods, such as ICA or NMF.
When you should not use XCP-D
XCP-D is not designed as a general-purpose postprocessing pipeline. It is really only appropriate for certain analyses, and other postprocessing/analysis tools are better suited for many types of data/analysis.
XCP-D derivatives are not particularly useful for task-dependent functional connectivity analyses, such as psychophysiological interactions (PPIs) or beta series analyses. It is also not suitable for general task-based analyses, such as standard task GLMs, as we recommend included nuisance regressors in the GLM step, rather than denoising data prior to the GLM.
Citing XCP-D
If you use XCP-D in your research, please use the boilerplate generated by the workflow. If you need an immediate citations, please cite the following preprint:
Mehta, K., Salo, T., Madison, T., Adebimpe, A., Bassett, D. S., Bertolero, M., ... & Satterthwaite, T. D. (2023). XCP-D: A Robust Pipeline for the post-processing of fMRI data. bioRxiv. doi:10.1101/2023.11.20.567926.
Please also cite the Zenodo DOI for the version you're referencing.