scilligence
commented
6 years ago The problem is how to intercept the * in the HELM. For example, for this HELM:
RNA1{R(A)P.R(U)P.*.R(T)P.R(G)}$$$$V2.0
Should the * be explained as a nucleotide(combo), or a isolated Ribose, or an extra Phophate. Since in HELM 2.0 they are also valid:
RNA1{R(A)P.R(U)P.R.R(T)P.R(G)}$$$$V2.0 --------------------^----------------------
RNA1{R(A)P.R(U)P.P.R(T)P.R(G)}$$$$V2.0 --------------------^----------------------
ClairePA
The combo unknown monomer puts two monomers into the molecule.
This is confusing as it looks like the represents a single monomer and there is no base. it would be better if there was a single monomer and it had a different shape (e.g. pentagon) to indicate that can mean anything.