Open qxsml opened 3 months ago
Excellent work.
Looking at the commonalities between the two compounds
I am tempted to suggest that we should also prepare/purchase and test the following as derivatives of RA-0010874
X= H, COOH, OH Further, we may also substitute the heterocycle attached to quinoline with other N-heterocycles (depending on the commercial availability).
Excellent work. Looking at the commonalities between the two compounds
I am tempted to suggest that we should also prepare/purchase and test the following as derivatives of RA-0010874
X= H, COOH, OH Further, we may also substitute the heterocycle attached to quinoline with other N-heterocycles (depending on the commercial availability).
Hi Rahman, thank you very much for your suggestion, X=H form is totally doable, SMs are cheap. I'm keen to try conditions in this paper https://doi.org/10.1039/C9OB00033J, very interesting. I'll leave the OH version for the 3rd expansion if the H version gave promising results.
Yes, a wonderful synthetic protocol for the suggested molecules!
After testing the 21 compounds and analyzing the results, please find the summary below.
![image](https://github.com/StructuralGenomicsConsortium/CNP12-Nsp15-TAMU/assets/147162201/9ad34c65-6ec1-4c49-b5c8-fe107898f00a)
A new series of compounds has been planned based on these results and is currently being synthesized for a second expansion. Please see below:![image](https://github.com/StructuralGenomicsConsortium/CNP12-Nsp15-TAMU/assets/147162201/03bab63d-8a57-45bf-bebf-171373f799fc)