CNP12-Nsp15-TAMU

An SGC Open Chemistry Networks Project (number 12) devoted to the target SARS-CoV-2 Nsp15.

More details can be found in wiki. Our current progress can be found here. Linkage to all the data can be found here

Our collective aim is to find a potent, selective, cell-penetrant, small-molecule inhibitor of Nsp15, an endoribonuclease of SARS-CoV-2. This will allow us to understand this target and kick-start drug discovery projects around it. The project is run as part of the READDI-AViDD consortium.

You contribute synthetic chemistry and in return the SGC/READDI offers biology. Everything is open, with all content governed by a CC-BY-4.0 licence.

If this sounds interesting, and you agree to the simple RULES, you can get started.

For answers to all the questions you have, go to the FAQs.

If you'd like to contact someone to talk about contributing, then write something in an Issue (see the tab above), which is a good way to communicate openly. (Issues describe what currently needs doing and act as a discussion forum - you need a Github account but it's super easy and not spammy. There's also an email address (chemistry@thesgc.org) you can use to ask questions. You can read more about all this in the "How To" Area

Some people involved in this project:

Chemistry:

Professor Matthew Todd, UCL, @mattodd

Dr Xin Qiu, UCL, @qxsml

Professor Tim Willson, @tmw20653

Dr Peter Brown, University North Carolina Chapel Hill, project manager @toluene44

Dr Anwar Hossain, UNC, @ahsgc

Biology:

Professor James Sacchettini, TAMU

Dr Inna Krieger, TAMU

Dr Da Di, TAMU

Dr Jelena (Habjanič) Thies, UCL

Dr Wenjie Cheng, UCL

Professor Nicholas Heaton, Duke University