CNP14-WDR91

An SGC Open Chemistry Networks Project 14 devoted to protein WDR91. This protein may be an important target for the creation of new host-directed antivirals. The aim of this project is to find a tight (micromolar) small molecule binder of this protein and extends the work described in this 2023 paper.

You contribute synthetic chemistry and in return the SGC offers biology. Together we can generate tool compounds to understand biology and validate drug targets to help cure disease. Everything is open, with all content governed by a CC-BY-4.0 licence.

If this sounds interesting, and you agree to the simple RULES, you can get started.

If you're here in response to the request for community inputs, you can find the specific ask here.

For the science background, head to the wiki or check out the living paper that is being written here <-- need to start.

For answers to all the questions you have, go to the FAQs.

If you'd like to contact someone to talk about contributing, then write something in an Issue (see the tab above), which is a good way to communicate openly. Issues describe what currently needs doing and act as a discussion forum - you need a Github account but it's super easy and not spammy. There's also an email address (chemistry@thesgc.org) you can use to ask questions. You can read more about all this in the "How To" Area.

People involved in this CNP:
Prof. Matthew Todd, UCL, Head of Chemistry Networks at the SGC @mattodd
Dr. Levon Halabelian, UofT, SGC Toronto
Dr. Suzanne Ackloo, UofT, SGC Toronto @szackloo
Dr. Santha Santhakumar, UofT, SGC Toronto @Santha-SGC
Dr. Shabbir Ahmad, UofT
Kangping Liu, UCL, PhD candidate in School of Pharmacy at UCL @KangpingL
Mohamad Sharizan, MPharm student, UCL @Mohamadshahir15 Prof. Matthieu Schapira, University of Toronto

You can see other contributors in the Issues (tab above).

The licence for the content of this project is, unless otherwise stated, and as for all OCN projects, CC-BY-4.0. This means you can do whatever you like with the project content, including making money, provided you cite the project.

This project is part of the SGC's Open Chemistry Networks initiative.