StructuralGenomicsConsortium CNP16-iminoquinone-SarsRdRp-mechanstic-study issues - Githubissues

StructuralGenomicsConsortium / CNP16-iminoquinone-SarsRdRp-mechanstic-study

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Exploring Reactivity of RA-0001351 with Various Nucleophiles

#10 qxsml opened 1 month ago
0
Synthesis and Characterization of the Adduct Formed Between RA-0001351 and Protected Cysteine

#9 qxsml opened 1 month ago
0
Computational Modeling Needed to Test Covalent Protein Modification Mechanism

#8 mattodd opened 1 month ago
11
Attempted reactions of RA-0001351 with protected cysteine under buffer conditions aiming to confirm that the made cysteine-RA1351 adduct was formed under buffer conditions.

#7 qxsml opened 4 months ago
4
google sheet update

#6 rahmanszsaleem closed 4 months ago
0
Attempted synthesis of iminoquinone-cysteine adducts: a protected cysteine-RA-1351 adduct was made, characterized using LCMS and 1H NMR, but C13 missing signals

#5 qxsml opened 8 months ago
6
Attempted monitoring/following the reaction of N-acetyl cysteine with RA-0001351 using NMR.

#4 qxsml closed 6 months ago
2
Conditions for the cysteine assay

#3 qxsml closed 4 months ago
1
Synthesis of the Original Hit "RA-0001351" and the subsequent cysteine adduct.

#2 qxsml opened 9 months ago
10
using N-acetyl cysteine as the substrate

#1 qxsml closed 2 months ago
7