This project aims to develop potent inhibitors of NSP14/NSP10 for the treatment of (CoV-19), Targeting the NSP14 and NSP10 interacting interface with small molecules or peptides could be a smart strategy to obstruct replication processes of coronaviruses (CoVs).
An overlap between fragments 18, 15, 12, 11, 10, 8, and 3 can be observed at the NSP14 and NSP10 interface based on fragalysis. The cluster of these fragments bound to the NSP14 protein is seen in the images below.
An overlap between fragments 18, 15, 12, 11, 10, 8, and 3 can be observed at the NSP14 and NSP10 interface based on fragalysis. The cluster of these fragments bound to the NSP14 protein is seen in the images below.