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StructuralGenomicsConsortium / CNP24-NSP10_14-Frags

This project aims to develop potent inhibitors of NSP14/NSP10 for the treatment of (CoV-19), Targeting the NSP14 and NSP10 interacting interface with small molecules or peptides could be a smart strategy to obstruct replication processes of coronaviruses (CoVs).
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CNP24-NSP10_14-Frags

An SGC Open Chemistry Networks Project (number 24) devoted to SARS-CoV-2 Nsp10/14. This project aims to develop small molecule binders of Nsp10/14 as starting points for medicines for future coronavirus pandemics. Our specific focus is the interface between the Nsp10 and 14 proteins, using a fragment screen as a starting point.

You contribute synthetic chemistry and in return the SGC offers biology. Together we can generate tool compounds to understand biology and validate drug targets to help cure disease. Everything is open, with all content governed by a CC-BY-4.0 licence.

If this sounds interesting, and you agree to the simple RULES, you can get started.

For the science background, head to the wiki or check out the living paper that is being written here.

For answers to all the questions you have, go to the FAQs.

If you'd like to contact someone to talk about contributing, then write something in an Issue (see the tab above), which is a good way to communicate openly. (Issues describe what currently needs doing and act as a discussion forum - you need a Github account but it's super easy and not spammy. There's also an email address (chemistry@thesgc.org) you can use to ask questions. You can read more about all this in the "How To" Area

Some people involved in this CNP:

Dr Hadia Almahli, Chemist at University College London @HadiaAmahli

Professor Matthew Todd, University College London. Head of Chemistry Networks at the SGC (medchem) @mattodd

Sharifah Nur Sabrina Binti Syed Azlan, MPharm student at University College London @shanursabrina

Dr. Joseph Newman, Scientist at Centre for Medicines Discovery, Oxford University, UK

Joshua Earl Hochuli, PhD student in computational Chemistry at UNC (University of North Carolina).

You can see other contributors in the Issues (tab above).

The licence for the content of this project is, unless otherwise stated, and as for all OCN projects, CC-BY-4.0. This means you can do whatever you like with the project content, including making money, provided you cite the project.

This project is part of the SGC's Open Chemistry Networks initiative.