18 Fragments showed binding interactions to the interface of nsP10/14- Fraglysis

StructuralGenomicsConsortium / CNP24-NSP10_14-Frags

This project aims to develop potent inhibitors of NSP14/NSP10 for the treatment of (CoV-19), Targeting the NSP14 and NSP10 interacting interface with small molecules or peptides could be a smart strategy to obstruct replication processes of coronaviruses (CoVs).

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18 Fragments showed binding interactions to the interface of nsP10/14- Fraglysis #4

Closed HadiaAmahli closed 4 months ago

HadiaAmahli commented 5 months ago

Fraglysis helped us to know the structure of the 18 fragments that showed interaction to the nsP10/14, their structure is as following:

The 18 fragments showed different clusters on the protein-protein interaction target, some of them are much bigger than others:

You can also see all these interactions by clicking this link: https://fragalysis.diamond.ac.uk/viewer/react/preview/target/NSP14/tas/lb18145-1

mattodd commented 4 months ago

Table taken from wiki and posted here for archiving: The overlay of all the structures were observed as the following table showing the overlapping between different fragments:

Closing this issue as the information is essentially on the wiki.