Currently in Wikidata, we have the property "drug used for treatment", which was mostly populated with the "may_treat" statements from NDFRT (Example), but also data based on in vitro experiments and clinical trials from CHEMBL (example: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1064). The later caused problems and (I think) were removed. The data from NDFRT is not very accurate or up to date either. (Example: ALATROFLOXACIN says it may treat infections in NDFRT, but it was pulled from the market in 2006)
We also have therapeutic area which is a less specific "disease area in which a medical intervention is applied". These are populated with disease areas from EMA (Example), and have dates associated, so drug removed from market are not represented. The therapeutic areas are mostly diseases, but not always (i.e. smoking cessation)
The property "may prevent" was recently added. Currently unused.
Diseases structured using drugbank IDs, not linked to anything else. commercial version includes a text description, severity, type of indication, and associated ICD10 or MedDRA identifiers
For drugs approved after 2012 disease annotations are extracted manually from approved drug labels and mapped to SNOMED-CT concepts. Targets are from chembl and WOMBAT-PK
"Surprisingly, we found that it was difficult to determine even the approved clinical indications for existing drugs. The availability of such information in public databases is highly variable, and in many cases, terminology is inconsistent. Using the NIH's DailyMed repository of FDA-approved drug-prescribing labels and other resources, we manually curated a dictionary of 644 unique drug-indication terms and assigned them to 1,918 launched drugs" paper
This is a database of drugs and what they were used for. Does not distinguish between types of therapies, does not distinguish between approved and therapeutic usages. For example, aspirin -> Myocardial infarction
if results are being reported and published, reference is provided
Many studies just completely lack any data except whether a study is active and recurting patients, because that's what study sponsors need to provide by law.
Notes regarding Drug Indications:
Currently in Wikidata, we have the property "drug used for treatment", which was mostly populated with the "may_treat" statements from NDFRT (Example), but also data based on in vitro experiments and clinical trials from CHEMBL (example: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1064). The later caused problems and (I think) were removed. The data from NDFRT is not very accurate or up to date either. (Example: ALATROFLOXACIN says it may treat infections in NDFRT, but it was pulled from the market in 2006)
We also have therapeutic area which is a less specific "disease area in which a medical intervention is applied". These are populated with disease areas from EMA (Example), and have dates associated, so drug removed from market are not represented. The therapeutic areas are mostly diseases, but not always (i.e. smoking cessation)
The property "may prevent" was recently added. Currently unused.
Potential Data Sources: