How to calculate the cell-type specific substitution score?

atarashansky / SAMap

SAMap: Mapping single-cell RNA sequencing datasets from evolutionarily distant organisms.

MIT License

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How to calculate the cell-type specific substitution score? #87

Closed huawen-poppy closed 2 years ago

huawen-poppy commented 2 years ago

Hello. In the SAMap paper, Figure 3B shows the barplot of the substitution score for all the cell types. I am wondering how to calculate such scores. Could you provide the relative function? Thanks in advance!

atarashansky commented 2 years ago

We used the ParalogSubstitutions function in samap.analysis to find paralog substitutions. The per-cell-type analysis is described below from the paper: