Shantanu Ghosh1
, Clare B. Poynton2
, Shyam Visweswaran3,
Kayhan Batmanghelich1
1BU ECE, 2 BUMC, 3 Pitt DBMI
/restricted/projectnb/batmanlab/shawn24/PhD
and replace it with your own path. E.g, .src/codebase/breastclip/data/datasets/imagetext.py
, change the json pathpunkt_tab
error, run the following command in the python environment:import nltk
nltk.download('punkt_tab')
After going through the instruction, it is recommended to visit the following queries logged in the issues:
If we hear more queries, we may add a separate FAQs in the future.
Use environment.yml to setup the environment.
git clone git@github.com:batmanlab/Mammo-CLIP.git
cd Mammo-CLIP
conda env create --name Mammo-CLIP -f environment.yml
conda activate Mammo-CLIP
Mammo-CLIP is implemented with following specification:
Download the original versions VinDr and RSNA from the links for downstream evaluations:
For the PNG images converted from the original Dicom images, as mentioned in the preprocessing steps in the paper, refer to the following links:
To preprocess the dicom images directly, follow the instructions in the next section. If you downloaded the PNG images, skip the preprocessing steps.
python ./src/preprocessing/preprocess_image_to_png_kaggle.py \
--phase="test" \
--base_folder="/restricted/projectnb/batmanlab/shawn24/PhD/RSNA_Breast_Imaging/Dataset/RSNA_Cancer_Detection"
python ./src/preprocessing/preprocess_image_to_png_vindr.py \
--phase="test" \
--base_folder="/restricted/projectnb/batmanlab/shawn24/PhD/RSNA_Breast_Imaging/Dataset/External/Vindr/vindr-mammo-a-large-scale-benchmark-dataset-for-computer-aided-detection-and-diagnosis-in-full-field-digital-mammography-1.0.0"
Our image-text dataset is an in-house dataset from UPMC. You can have your own image+text dataset where images are 2D
mammograms and texts are radiology reports. If you have access to such dataset, follow the setup here. Extract the IMPRESSION
and FINDINGS
sections from the
report and create a csv. The sample
csv: upmc_dicom_consolidated_final_folds_BIRADS_num_1_report.csv
Note the FINDINGS
and IMPRESSION
columns are
used to generate the text for the image. The HISTORY
, FINDINGS
and IMPRESSION
columns contains templated text
due to privacy.
Next run the following command to augment the text with upmc_dicom_consolidated_final_folds_BIRADS_num_1_report.csv
file:
# input: upmc_dicom_consolidated_final_folds_BIRADS_num_1_report.csv
# output: clip_pretrain_100.csv
python ./src/codebase/augment_text.py \
--dataset-path="/restricted/projectnb/batmanlab/shawn24/PhD/Mammo-CLIP/src/codebase/data_csv" \
--csv-path="upmc_dicom_consolidated_final_folds_BIRADS_num_1_report.csv" \
--dataset="upmc"
The augment_text.py
script will do the preprocessing for the FINDINGS
and IMPRESSION
columns by converting them to
lower case and removing punctuations. Look at the _split_report_into_segment_concat
function in the script for more
details.
index | patient_id | laterality | image | view | CC | MLO | text | text_augment |
---|---|---|---|---|---|---|---|---|
0 | patient_id | laterality ('R' or 'L') | List of all image_paths for patient_id-laterality combo | List of views for patient_id-laterality combo (only 'CC' and 'MLO' are used) | List of image paths for CC view for patient_id-laterality combo | List of image paths for MLO view for patient_id-laterality combo | List of [findings, impression] | List of [augmented findings, augmented impression] |
step3
is
here: clip_pretrain_100.csv. clip_pretrain_100.csv
is used for pretraining the image-text variant of Mammo-CLIP.We use VinDr dataset as image-label dataset though it can be expanded to any such datasets. Make sure that every patient should have atleast one CC and MLO image per laterality. So if you are planning to use it in the pre-training setup, use the following notebook to preprocess the VinDr dataset:
./src/codebase/notebooks/preprocess-clip/VinDr.ipynb
When you download the VinDr dataset, you will get these two csv
files: breast-level_annotations.csv
and finding_annotations.csv
. We preprocess the finding_annotations.csv
file to
get vindr_detection_v1_folds.csv
. VinDr.ipynb
notebook requires vindr_detection_v1_folds.csv file as input and
generate clip_vindr_final.csv
file.
Both clip_pretrain_100.csv and clip_vindr_final.csv files are used for pretraining the image-text and image-label variant of Mammo-CLIP.
The csv file of the final image-label (VinDr) dataset should have the following format:
index | patient_id | laterality | image | view | CC | MLO | CC_FINDING | MLO_FINDING |
---|---|---|---|---|---|---|---|---|
0 | patient_id | laterality ('R' or 'L') | List of all image_paths for patient_id-laterality combo | List of views for patient_id-laterality combo (only 'CC' and 'MLO' are used) | List of image paths for CC view for patient_id-laterality combo, e.g, [CC_img ..] | List of image paths for MLO view for patient_id-laterality combo, e.g, [MLO_img .. ] | Findings per image per laterality for CC view (see below for the format) | Findings per image per laterality for MLO view (see below for the format) |
Explanation for CC_FINDING and MLO_FINDING Columns: In the above table, for the row, CC_FINDING can be expanded as:
[
[+ve findings for CC_img if laterality of CC_img is R],
[+ve findings for CC_img if laterality of CC_img is L],
[-ve findings for CC_img if laterality of CC_img is R],
[-ve findings for CC_img if laterality of CC_img is L],
]
As VinDr contains a single image per patient-laterality combo, we did n
Similarly, in the above table, for the row, MLO_FINDING can be expanded as:
[
[+ve findings for MLO_img if laterality of MLO_img is R],
[+ve findings for MLO_img if laterality of MLO_img is L],
[-ve findings for MLO_img if laterality of MLO_img is R],
[-ve findings for MLO_img if laterality of MLO_img is L],
]
Use the following csv files as metadata for the downstream tasks (classification, detection, zero-shot):
Dataset | CSV |
---|---|
VinDr | vindr_detection_v1_folds.csv |
RSNA | train_folds.csv |
For detection/localization tasks, we have included the coordinates of the resized bounding boxes of VinDr in the above csv file. Somebody interested in resizing the bounding boxes by themselves, run the following command with finding_annotations.csv file as input:
python ./src/preprocessing/preprocess_VinDr_detector.py
.
├── list_tree_files.sh
├── upmc_dicom_consolidated_final_folds_BIRADS_num_1_report.csv
├── clip_pretrain_100.csv
└── DICOM/images_png_CC_MLO/
├── Patient_100/
│ ├── 1.png
│ ├── 2.png
└── Patient_200/
├── 3.png
├── 4.png
├── 53.png
├── 6.png
└── 7.png
.
├── breast-level_annotations.csv
├── finding_annotations.csv
├── vindr_detection_v1_folds.csv
├── clip_vindr_final.csv
└── images_png/
├── c7811f4575c1229ad4a7606de49ea68f/
│ ├── 9eb4650a2b630e44074c403f6127c5a1.png
│ ├── cc3fdc5d733a671f3000e20838e192d9.png
│ ├── 181fd193d3b785dc9faafdaa8e1695fc.png
│ └── 55eb5ea616abacd225e584ffc8be57da.png
└── a1dd219b28806fc295fac20ceb147870/
├── 887cdcc99ebed66bd062ada6c8210152.png
├── 36f2921a2ac19eba7420c591c4c07ae4.png
├── 12dc17dfd9d30ea7c0c1ccb33a505085.png
└── e22e4f297b4c82279e7b78a98417a6cd.png
.
├── train_folds.csv
├── train_images_png/
├── 59549/
│ ├── 1154694388.png
│ ├── 1192817932.png
│ ├── 1979035704.png
│ ├── 2022274082.png
│ ├── 431013616.png
│ ├── 457600713.png
│ ├── 78005871.png
│ └── 856162422.png
└── 28242/
├── 1966298736.png
├── 233201459.png
├── 349787619.png
└── 98615814.png
Following are the pre-training checkpoints of Mammo-CLIP:
Model architecture | Checkpoints (Google drive) | Checkpoints (Hugging Face) |
---|---|---|
Best performance | Efficient-Net B5 | Efficient-Net B5 |
Lightweight | Efficient-Net B2 | Efficient-Net B2 |
We have also uploaded the downstream checkpoints for classification and localization (both linear probe and finetuning) with the image encoder of Efficient-Net B5 Mammo-CLIP for fold 0 here.
For pretraining Efficient-Net B5 Mammo-CLIP with a single GPU, use the following command:
python ./src/codebase/train.py --config-name pre_train_b5_clip.yaml
For pretraining Efficient-Net B5 Mammo-CLIP with a 4 GPUs using pytorch-ddp, use the following command:
torchrun --nproc_per_node=4 ./src/codebase/train.py --config-name pre_train_b5_clip.yaml
All the yaml
files for the config are
found here.
BreastClipClassifier
in breast-clip-classifier.py
file.RetinaNet_efficientnet
in detector_model.py
file.FOLD=0
CKPT="b2-model-best-epoch-10.tar"
DIR="./Mammo-CLIP/src/codebase/outputs/upmc_clip/b2_detector_period_n"
FULL_CKPT="$DIR/checkpoints/fold_$FOLD/$CKPT"
python ./src/codebase/eval_zero_shot_clip.py \
--config-name zs_clip.yaml hydra.run.dir=$DIR model.clip_check_point=$FULL_CKPT
Adjust the CKPT
and DIR
variables according to your setup.
python ./src/codebase/train_classifier.py \
--data-dir '/restricted/projectnb/batmanlab/shawn24/PhD/RSNA_Breast_Imaging/Dataset' \
--img-dir 'External/Vindr/vindr-mammo-a-large-scale-benchmark-dataset-for-computer-aided-detection-and-diagnosis-in-full-field-digital-mammography-1.0.0/images_png' \
--csv-file 'External/Vindr/vindr-mammo-a-large-scale-benchmark-dataset-for-computer-aided-detection-and-diagnosis-in-full-field-digital-mammography-1.0.0/vindr_detection_v1_folds.csv' \
--clip_chk_pt_path "/restricted/projectnb/batmanlab/shawn24/PhD/Mammo-CLIP/src/codebase/outputs/upmc_clip/b5_detector_period_n/checkpoints/fold_0/b5-model-best-epoch-7.tar" \
--data_frac 1.0 \
--dataset 'ViNDr' \
--arch 'upmc_breast_clip_det_b5_period_n_lp' \
--label "Mass" \
--epochs 30 \
--batch-size 8 \
--num-workers 0 \
--print-freq 10000 \
--log-freq 500 \
--running-interactive 'n' \
--n_folds 1 \
--lr 5.0e-5 \
--weighted-BCE 'y' \
--balanced-dataloader 'n'
data-dir
: root directory of the datasetimg-dir
: directory containing images, absolute path: data-dir/img-dir
csv-file
: csv file containing image paths and labels, absolute path: data-dir/csv-file
clip_chk_pt_path
: path to the checkpoint of the pre-trained Mammo-CLIP modeldataset
: dataset name, e.g., ViNDr
or RSNA
data_frac
: fraction of the dataset to use for training, e.g., 1.0
, 0.5
etcarch
: architecture of the model, e.g., upmc_breast_clip_det_b5_period_n_lp
for Efficient-Net B5
or upmc_breast_clip_det_b2_period_n_lp
for Efficient-Net B2, pretrained on UPMC dataset.
Also, upmc_vindr_breast_clip_det_b5_period_n_lp
for Efficient-Net B5
or upmc_vindr_breast_clip_det_b2_period_n_lp
for Efficient-Net B2, pretrained on UPMC and VinDr datasets.label
: target label for classification, e.g., Mass
, Suspicious_Calcification
or density
for ViNDr
dataset; cancer
for RSNA datasetrunning-interactive
: running on interactive mode. In this mode,the training will be done using 100 samples for
sanity checkpython ./src/codebase/train_classifier.py \
--data-dir '/restricted/projectnb/batmanlab/shawn24/PhD/RSNA_Breast_Imaging/Dataset' \
--img-dir 'External/Vindr/vindr-mammo-a-large-scale-benchmark-dataset-for-computer-aided-detection-and-diagnosis-in-full-field-digital-mammography-1.0.0/images_png' \
--csv-file 'External/Vindr/vindr-mammo-a-large-scale-benchmark-dataset-for-computer-aided-detection-and-diagnosis-in-full-field-digital-mammography-1.0.0/vindr_detection_v1_folds.csv' \
--clip_chk_pt_path "/restricted/projectnb/batmanlab/shawn24/PhD/Mammo-CLIP/src/codebase/outputs/upmc_clip/b5_detector_period_n/checkpoints/fold_0/b5-model-best-epoch-7.tar" \
--data_frac 1.0 \
--dataset 'ViNDr' \
--arch 'upmc_breast_clip_det_b5_period_n_ft' \
--label "Mass" \
--epochs 30 \
--batch-size 8 \
--num-workers 0 \
--print-freq 10000 \
--log-freq 500 \
--running-interactive 'n' \
--n_folds 1 \
--lr 5.0e-5 \
--weighted-BCE 'y' \
--balanced-dataloader 'n'
data-dir
: root directory of the datasetimg-dir
: directory containing images, absolute path: data-dir/img-dir
csv-file
: csv file containing image paths and labels, absolute path: data-dir/csv-file
clip_chk_pt_path
: path to the checkpoint of the pre-trained Mammo-CLIP modeldataset
: dataset name, e.g., ViNDr
or RSNA
data_frac
: fraction of the dataset to use for training, e.g., 1.0
, 0.5
etcarch
: arch
: architecture of the model, e.g., upmc_breast_clip_det_b5_period_n_ft
for Efficient-Net B5
or upmc_breast_clip_det_b2_period_n_ft
for Efficient-Net B2, pretrained on UPMC dataset.
Also, upmc_vindr_breast_clip_det_b5_period_n_ft
for Efficient-Net B5
or upmc_vindr_breast_clip_det_b2_period_n_ft
for Efficient-Net B2, pretrained on UPMC and VinDr datasets.label
: target label for classification, e.g., Mass
, Suspicious_Calcification
or density
for ViNDr
dataset; cancer
for RSNA datasetrunning-interactive
: running on interactive mode. In this mode,the training will be done using 100 samples for
sanity checkpython ./src/codebase/train_detector.py \
--data-dir '/restricted/projectnb/batmanlab/shawn24/PhD/RSNA_Breast_Imaging/Dataset' \
--img-dir 'External/Vindr/vindr-mammo-a-large-scale-benchmark-dataset-for-computer-aided-detection-and-diagnosis-in-full-field-digital-mammography-1.0.0/images_png' \
--csv-file 'External/Vindr/vindr-mammo-a-large-scale-benchmark-dataset-for-computer-aided-detection-and-diagnosis-in-full-field-digital-mammography-1.0.0/vindr_detection_v1_folds.csv' \
--clip_chk_pt_path "/restricted/projectnb/batmanlab/shawn24/PhD/Mammo-CLIP/src/codebase/outputs/upmc_clip/b5_detector_period_n/checkpoints/fold_0/b5-model-best-epoch-7.tar" \
--dataset 'ViNDr' \
--arch 'clip_b5_upmc' \
--epochs 120 \
--batch-size 7 \
--freeze_backbone "y" \
--data_frac 1.0 \
--concepts 'Mass' \
--print-freq 5000 \
--log-freq 300 \
--running-interactive 'n' \
--focal-alpha 0.25 \
--focal-gamma 2.0 \
--score-threshold 0.2
data-dir
: root directory of the datasetimg-dir
: directory containing images, absolute path: data-dir/img-dir
csv-file
: csv file containing image paths and labels, absolute path: data-dir/csv-file
clip_chk_pt_path
: path to the checkpoint of the pre-trained Mammo-CLIP modeldataset
: dataset name, e.g., ViNDr
data_frac
: fraction of the dataset to use for training, e.g., 1.0
, 0.5
etcarch
: architecture of the model, e.g., clip_b5_upmc
for Efficient-Net B5 or clip_b2_upmc
for Efficient-Net B2,
pretrained on UPMC dataset. Similarly, clip_b5_upmc_vindr
for Efficient-Net B5 or clip_b2_upmc_vindr
for
Efficient-Net B2,
pretrained on UPMC and VinDr datasets.concepts
: target label for classification, e.g., Mass
, Suspicious Calcification
for ViNDr datasetrunning-interactive
: running on interactive mode. In this mode,the training will be done using 100 samples for
sanity checkfreeze_backbone
: freeze the backbone of the model, for linear probe, set to y
python ./src/codebase/train_detector.py \
--data-dir '/restricted/projectnb/batmanlab/shawn24/PhD/RSNA_Breast_Imaging/Dataset' \
--img-dir 'External/Vindr/vindr-mammo-a-large-scale-benchmark-dataset-for-computer-aided-detection-and-diagnosis-in-full-field-digital-mammography-1.0.0/images_png' \
--csv-file 'External/Vindr/vindr-mammo-a-large-scale-benchmark-dataset-for-computer-aided-detection-and-diagnosis-in-full-field-digital-mammography-1.0.0/vindr_detection_v1_folds.csv' \
--clip_chk_pt_path "/restricted/projectnb/batmanlab/shawn24/PhD/Mammo-CLIP/src/codebase/outputs/upmc_clip/b5_detector_period_n/checkpoints/fold_0/b5-model-best-epoch-7.tar" \
--dataset 'ViNDr' \
--arch 'clip_b5_upmc' \
--epochs 120 \
--batch-size 7 \
--freeze_backbone "n" \
--data_frac 1.0 \
--concepts 'Mass' \
--print-freq 5000 \
--log-freq 300 \
--running-interactive 'n' \
--focal-alpha 0.25 \
--focal-gamma 2.0 \
--score-threshold 0.2
data-dir
: root directory of the datasetimg-dir
: directory containing images, absolute path: data-dir/img-dir
csv-file
: csv file containing image paths and labels, absolute path: data-dir/csv-file
clip_chk_pt_path
: path to the checkpoint of the pre-trained Mammo-CLIP modeldataset
: dataset name, e.g., ViNDr
data_frac
: fraction of the dataset to use for training, e.g., 1.0
, 0.5
etcarch
: architecture of the model, e.g., clip_b5_upmc
for Efficient-Net B5 or clip_b2_upmc
for Efficient-Net B2,
pretrained on UPMC dataset. Similarly, clip_b5_upmc_vindr
for Efficient-Net B5 or clip_b2_upmc_vindr
for
Efficient-Net B2,
pretrained on UPMC and VinDr datasets.concepts
: target label for classification, e.g., Mass
, Suspicious Calcification
for ViNDr datasetrunning-interactive
: running on interactive mode. In this mode,the training will be done using 100 samples for
sanity checkfreeze_backbone
: freeze the backbone of the model, for finetune, set to n
For all the training scripts, we add them in the scripts directory:
Scripts | Purpose |
---|---|
pretrain_mammo_clip_b5.sh | Pretrain Mammo-CLIP b5 with image+text data |
pretrain_mammo_clip_b5_ddp.sh | Pretrain Mammo-CLIP b5 with image+text data using multiple GPUs |
pretrain_mammo_clip_b2.sh | Pretrain Mammo-CLIP b2 with image+text data |
pretrain_mammo_clip_b2_ddp.sh | Pretrain Mammo-CLIP b2 with image+text data using multiple GPUs |
pretrain_mammo_clip_w_vindr_b5.sh | Pretrain Mammo-CLIP b5 with image+text data and image+label data |
classifier_fine_tune_b5.sh | Evaluate Mammo-CLIP b5 on fine tuning tasks for classification |
classifier_fine_tune_b2.sh | Evaluate Mammo-CLIP b2 on fine tuning tasks for classification |
classifier_linear_probe_b5.sh | Evaluate Mammo-CLIP b5 on linear probing tasks for classification |
classifier_linear_probe_b2.sh | Evaluate Mammo-CLIP b2 on linear probing tasks for classification |
detector_fine_tune_b5.sh | Evaluate Mammo-CLIP b5 on fine tuning tasks for detection |
detector_fine_tune_b2.sh | Evaluate Mammo-CLIP b2 on fine tuning tasks for detection |
detector_linear_probe_b5.sh | Evaluate Mammo-CLIP b5 on linear probing tasks for detection |
detector_linear_probe_b2.sh | Evaluate Mammo-CLIP b2 on linear probing tasks for detection |
For training Mammo-FActOR, refer to the following notebook.
@InProceedings{10.1007/978-3-031-72390-2_59,
author="Ghosh, Shantanu
and Poynton, Clare B.
and Visweswaran, Shyam
and Batmanghelich, Kayhan",
editor="Linguraru, Marius George
and Dou, Qi
and Feragen, Aasa
and Giannarou, Stamatia
and Glocker, Ben
and Lekadir, Karim
and Schnabel, Julia A.",
title="Mammo-CLIP: A Vision Language Foundation Model to Enhance Data Efficiency and Robustness in Mammography",
booktitle="Medical Image Computing and Computer Assisted Intervention -- MICCAI 2024",
year="2024",
publisher="Springer Nature Switzerland",
address="Cham",
pages="632--642",
abstract="The lack of large and diverse training data on Computer-Aided Diagnosis (CAD) in breast cancer detection has been one of the concerns that impedes the adoption of the system. Recently, pre-training with large-scale image text datasets via Vision-Language models (VLM) (e.g., CLIP) partially addresses the issue of robustness and data efficiency in computer vision (CV). This paper proposes Mammo-CLIP, the first VLM pre-trained on a substantial amount of screening mammogram-report pairs, addressing the challenges of dataset diversity and size. Our experiments on two public datasets demonstrate strong performance in classifying and localizing various mammographic attributes crucial for breast cancer detection, showcasing data efficiency and robustness similar to CLIP in CV. We also propose Mammo-FActOR, a novel feature attribution method, to provide spatial interpretation of representation with sentence-level granularity within mammography reports. Code is available publicly: https://github.com/batmanlab/Mammo-CLIP.",
isbn="978-3-031-72390-2"
}
Licensed under the Creative Commons Attribution 4.0 International
Copyright © Batman Lab, 2024
For any queries, contact Shantanu Ghosh (email: shawn24@bu.edu)
Special thanks to Boston University Masters students Abhishek Varshney & Akshat Gurbuxani for enabling multi-GPU support to Mammo-CLIP.
Did you try Mammo-CLIP on other datasets containing 2D-Mammograms and want to report the results? Feel free to send a pull request.