In it, the authors provide an interaction network of receptors with ligands and their biosynthetic enzymes. The latter is particularly interesting, as the enzymes are either catalyzing the last reaction step or the bottleneck - similar to the approach in CellPhoneDBv4.
We should add the database from the following manuscript: https://www.cell.com/cell-genomics/fulltext/S2666-979X(24)00123-X
In it, the authors provide an interaction network of receptors with ligands and their biosynthetic enzymes. The latter is particularly interesting, as the enzymes are either catalyzing the last reaction step or the bottleneck - similar to the approach in CellPhoneDBv4.
ligand-receptor-enzyme-family knowledge is here: https://gpcrcanceraxes.bioinfolab.sns.it/ available via the
Downloadbutton.While full knowledge from RheaDB with PubMed IDs is provided in Table S2 in the manuscript.