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broadinstitute / getzlab-LNP

Log-normal-Poisson regression model from Hess et al. 2019
https://doi.org/10.1016/j.ccell.2019.08.002
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Run LNP model from gene mutation file #2

Open gxiefanfan123 opened 2 years ago

gxiefanfan123 commented 2 years ago

The LNP model is an excellent method to call Passenger Hotspot . I have assess of matlab. But following the demo instruction, I can't run it successfully. Actually, during the analysis, the start input file is the gene mutation file. So could you provide an demo from the mutaion as the input file to run the LNP model in the other study.

julianhess commented 2 years ago

This repo contains generic code for running a log-normal Poisson regression on any count data, given arbitrary covariates (both continuous and categorical). It is not specific to somatic mutation data.

For applying this model specifically to recurrent somatic mutations, please see the companion repository.