See CONTRIBUTING.md.
Navigate to https://lof.curation.broadinstitute.org/projects.
Click "Create project", name the project (often this is the gene symbol, e.g. 'PCSK9')
Create a list of variants using the script
For a single gene
python scripts/get_gnomad_lof_variants.py --gene-ids ENSG00000169174 --gnomad-version 4 --output ./data/PCSK9.json
For a list of variants
python scripts/get_gnomad_lof_variants.py --gnomad-version 4 --variants-file ./data/input_variants.csv --output ./data/output_variants.json
Navigate back to the portal, on the project click "Upload variants"
Upload the list of variants generated by the script
Add the emails of the project leads(s) as additional project owners