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cnellington / Contextualized

An SKLearn-style toolbox for estimating and analyzing models, distributions, and functions with context-specific parameters.
http://contextualized.ml/
GNU General Public License v3.0
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Cell-specific Contexts #6

Closed blengerich closed 2 years ago

blengerich commented 2 years ago

Using ATAC->RNA linking is most biologically meaningful, but reduces the number of modalities we have to provide context. Let's think about how we can define cell-specific contexts. One possibility: define a set of genes/peaks which provide cell "state" but we don't care about therir regulation. Another possibility: use dim-reduced version of the full data, leaning into the interpretation of cell-specific networks as locally-linear views of a global network.

blengerich commented 2 years ago

More appropriate for sc-contextualized.ml, moving issue there.