A method for querying newly generated organoid single-cell RNA sequencing (scRNA-seq) data to the Human Endoderm Organoid Cell Atlas (HEOCA). HEOCA is an integrated single-cell transcriptome collection that includes 218 samples from organoids derived from various endoderm tissues, including the lung, pancreas, intestine, liver, biliary system, stomach, and prostate. This current version of HEOCA includes nearly one million cells from a variety of conditions, data sources, and protocols.
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An integrated transcriptomic cell atlas of human endoderm-derived organoids. Quan Xu, Lennard Halle, Soroor Hediyeh-zadeh, Merel Kuijs, Umut Kilik, Qianhui Yu, Tristan Frum, Lukas Adam, Shrey Parikh, Manuel Gander, Raphael Kfuri-Rubens, Dominik Klein, Zhisong He, Jonas Simon Fleck, Koen Oost, Maurice Kahnwald, Silvia Barbiero, Olga Mitrofanova, Grzegorz Maciag, Kim B. Jensen, Matthias Lutolf, Prisca Liberali, Joep Beumer, Jason R. Spence, Barbara Treutlein, Fabian J. Theis, J. Gray Camp. bioRxiv 2023.11.20.567825; doi: https://doi.org/10.1101/2023.11.20.567825