This file is part of GO-PCA.

GO-PCA is free software: you can redistribute it and/or modify
it under the terms of the GNU General Public License, Version 3,
as published by the Free Software Foundation.

This program is distributed in the hope that it will be useful,
but WITHOUT ANY WARRANTY; without even the implied warranty of
MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
GNU General Public License for more details.

You should have received a copy of the GNU General Public License
along with this program. If not, see <http://www.gnu.org/licenses/>.

GO-PCA

GO-PCA (Wagner, 2015__) is an unsupervised method to explore gene expression data using prior knowledge. This is a free and open-source implementation of GO-PCA in Python.

__ go_pcapaper

Briefly, GO-PCA combines principal component analysis (PCA) with nonparametric GO enrichment analysis in order to generate signatures, i.e., small sets of genes that are both strongly correlated and closely functionally related. It then visualizes the expression profiles of all signatures in a signature matrix, designed to serve as a systematic and easily interpretable representation of biologically relevant expression patterns.

_ pca __ goenrich

.. _go_pca_paper: https://dx.doi.org/10.1371/journal.pone.0143196 .. _pca: https://en.wikipedia.org/wiki/Principal_component_analysis .. _go_enrich: https://dx.doi.org/10.1186/1471-2105-10-48

Support and Development

For feature requests and bug reports, please create an issue__ on GitHub.
For technical questions, please feel free to email__.
If you want to contribute code to GO-PCA, please email__ and/or create a pull request on GitHub.
For a list of the latest changes, please see the Changelog <CHANGELOG.rst>_.

githubissue email_ _ email

.. _github_issue: https://github.com/flo-compbio/gopca/issues .. _email: mailto:florian.wagner@duke.edu

How to Cite GO-PCA

If you use GO-PCA in your research, please cite Wagner (PLoS One, 2015)__

__ wagnerpone

.. _wagner_pone: https://dx.doi.org/10.1371/journal.pone.0143196

Copyright and License

GO-PCA is free software: you can redistribute it and/or modify it under the terms of the GNU General Public License, Version 3, as published by the Free Software Foundation.

This program is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU General Public License for more details.

You should have received a copy of the GNU General Public License along with this program. If not, see http://www.gnu.org/licenses/.

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