hammerlab / immuno

Use somatic mutations to choose a personalized cancer vaccine (tumor-specific immunogenic peptides)
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RETIRED: See vaxrank and epidisco instead

Immunotherapy Pipeline

Status

Build Status

Usage

From peptide string

python mutation_report.py --string EDLTVKIGDFGLATEKSRWSGSHQFEQLS --hla "HLA-B*35:01"

From input file

python mutation_report.py --input-file <.vcf, .maf, .tab, .fasta> --hla-file <allele-file> 

If VCF file is input, it will be annotated w/ gene information and Ensembl transcripts, otherwise input an annotated SnpEFF VCF file.

If you don't either an hla or hla-file then the default "HLA:A*02:01" will be used.

Options:

Requirements

You must either have netMHCpan installed locally or pass the iedb-mhc flag to use a web-based MHC binding predictor.